NDLI: Release behavior of tetracycline hydrochloride loaded chitosan/poly(lactic acid) antimicrobial nanofibrous membranes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jiang, Suwei Lv, Jian Ding, Man Li, Yanan Wang, Hualin Jiang, Shaotong
Description	Author Affiliation: Jiang S ( School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China.); Lv J ( School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China.); Ding M ( School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China.); Li Y ( School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China.); Wang H ( School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China); Jiang S ( School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China)
Abstract	The present work aimed to evaluate the release behavior of tetracycline hydrochloride loaded chitosan/poly(lactic acid) (Tet-CS/PLA) antimicrobial nanofibrous membranes fabricated via electrospinning technique. The electrospinning solution was a blend of Tet, CS formic acid solution and PLA chloroform/ethanol solution. The interaction between CS and PLA in CS/PLA nanofibers was confirmed to be hydrogen bond. The incorporation of Tet caused a slight decrease in the diameter of nanofibers with Tet content below 30%. Tet-CS/PLA nanofibrous membrane showed a slight initial burst within the first 4h before a gradual increase in cumulative release, and the release percentage increased with increasing Tet contents. Tet release (Mt/M∞<0.6) from the medicated nanofibers could be described by Fickian diffusion model and the release profiles showed two sequential stages. Tet-CS/PLA nanofibrous membranes exhibited an effective and sustainable inhabitance on the growth of Staphylococcus aureus, and the antimicrobial activity increased rapidly with increasing Tet contents below 20%. Furthermore, the incorporation of Tet promoted the degradation of nanofibrous membranes.
File Format	HTM / HTML
ISSN	09284931
Volume Number	59
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2016-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Chitosan Chemistry Lactic Acid Membranes, Artificial Nanofibers Polymers Staphylococcus Aureus Growth & Development Tetracycline Delayed-action Preparations Pharmacokinetics Pharmacology Polyesters Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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