NDLI: Fine-resolution elastic-property maps of myopic sclera by means of acoustic microscopy

Content Provider	IEEE Xplore Digital Library
Author	Rohrbach, D. Hoang, Q.V. Quan Wen McFadden, S.A. Silverman, R.H. Mamou, J.
Copyright Year	2015
Description	Author affiliation: Hunter Med. Res. Inst., Univ. of Newcastle, Newcastle, NSW, Australia (McFadden, S.A.) \|\| Dept. of Ophthalmology, Columbia Univ., New York, NY, USA (Hoang, Q.V.; Quan Wen) \|\| Lizzi Center for Biomed. Eng., New York, NY, USA (Rohrbach, D.; Silverman, R.H.; Mamou, J.)
Abstract	Myopia is caused by excessive axial eye length, which results in images focused in front of the retina. High (pathologic) myopia can lead to irreversible vision loss. The anatomic changes underlying excessive eye elongation likely occur in the eye wall (sclera), which becomes more flexible than in non-myopic eyes. In the present study, we employed a form-deprivation (FD), guinea pig myopia model and a scanning acoustic microscope (SAM) to study biomechanical properties in the sclera at microscopic levels. 12-μm-thick cryosections of sclera from 7 animals with varying levels of induced myopia were measured using a custom-built SAM. To induce myopia, each animal wore a translucent diffuser in front of the right eye from 4-12 days of life. Intraocular differences in refractive error ranged between -3.2 D to -9.3 D. The SAM was equipped with an F-1.16, 250-MHz transducer with a 160-MHz bandwidth and that provided a 7-μm lateral beam width. Maps of the speed-of-sound (c), acoustic impedance (Z), attenuation (a), Bulk modulus (K) and mass density (ρ) were derived from the frequency-domain representation of each recorded signal using a model-based approach. For the animal with the greatest myopia, values of K, ρ, α, c and Z in the control eye were significantly higher (p<;0.05) at the inferior sclera. Moreover, K, c and Z were lower in the myopic eye in the inferior sclera. The results demonstrate the feasibility of assessing scleral material properties at very fine resolutions and indicate that myopia-related changes in those properties vary by location in the sclera. The fine-resolution quantitative images obtained in this study may be valuable in the investigation of the biomechanical properties of ocular tissues in diseases where tissue elasticity plays a role such as in myopia.
Starting Page	1
Ending Page	4
File Size	1221285
Page Count	4
File Format	PDF
e-ISBN	9781479981823
DOI	10.1109/ULTSYM.2015.0169
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-10-21
Publisher Place	Taiwan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Acoustics Animals Microscopy Material properties Retina Optical filters Optical imaging elastic properties Scanning acoustic microscopy myopia guinea pig
Content Type	Text
Resource Type	Article

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