NDLI: Backscatter coefficient estimation from human thyroid in vivo

Content Provider	IEEE Xplore Digital Library
Author	Cueva, T. Rouyer, J. Lavarello, R. Portal, A. Yamamoto, T.
Copyright Year	2015
Description	Author affiliation: Dept. de Ing., Pontificia Univ. Catolica del Peru, Lima, Peru (Cueva, T.; Rouyer, J.; Lavarello, R.) \|\| Dept. de Radiologia, Clinica Centenario Peruano Japonesa, Lima, Peru (Portal, A.; Yamamoto, T.)
Abstract	Currently, fine-needle aspiration (FNA) biopsy is the gold standard for the diagnosis of thyroid cancer. Therefore, there is a need to develop non-invasive tools that aid in the identification of malignant tissues in this gland. Quantitative ultrasound imaging using backscatter coefficients (BSCs) has shown potential to characterize thyroid tissues in rodent models ex vivo. As an initial step towards the goal of thyroid cancer diagnosis on a clinical setting, in this study the feasibility of BSC-based imaging in humans in vivo is evaluated. Radiofrequency data was collected using a scanner equipped with a 9-MHz linear probe from ten patients with no clinical records of thyroid disease and no thyroid nodules visible through ultrasonic examination. Backscatter coefficients were estimated using the reference phantom method and considering analysis regions of 4.5 mm by 4.5 mm. Attenuation compensation was performed considering the presence of sub-cutaneous fat, muscle, and thyroid tissues. Images were constructed by calculating the mean BSC within the analysis bandwidth spanning from 3 to 8 MHz The average value of the backscatter coefficients in normal thyroids was 0.056±0.037 1/(sr.cm) within the analysis bandwidth. The coefficient of variation of the mean BSC values of all the thyroid samples was less than 2dB. These results suggest that consistent imaging of BSC-derived parameters from human thyroids in vivo is possible and may play a role in thyroid tissue characterization.
Starting Page	1
Ending Page	4
File Size	1305355
Page Count	4
File Format	PDF
e-ISBN	9781479981823
DOI	10.1109/ULTSYM.2015.0407
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-10-21
Publisher Place	Taiwan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Cancer Backscatter Ultrasonic imaging Attenuation Acoustics Phantoms quantitative imaging quantitative ultrasound tissue characterization backscatter coefficient thyroid
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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