Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Yohan Kim Fifer, C.G. Gelehrter, S.K. Williams, J. Lu, J.C. Cain, C.A. Zhen Xu |
| Copyright Year | 2009 |
| Description | Author affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, USA (Yohan Kim; Zhen Xu) || Department of Pediatric Cardiology, Medical School, University of Michigan, Ann Arbor, 48109, USA (Fifer, C.G.; Gelehrter, S.K.; Lu, J.C.) || Department of Obstetrics and Gynecology, Medical School, University of Michigan, Ann Arbor, 48109, USA (Williams, J.) |
| Abstract | Pulsed cavitational ultrasound, or histotripsy, has been shown to be an effective technique to mechanically fractionate tissue through controlled cavitation. In this study, we investigate the feasibility of using histotripsy as a therapeutic tool to non-invasively fractionate and remove fetal tissue. Pregnant ewes at 102–129 days into gestation were exposed to histotripsy by a focused 1 MHz transducer coupled to the maternal abdominal wall. The fetal heart, kidney and liver were exposed to short ultrasound pulses (≪10 µs) at a 1 kHz pulse repetition rate and 10–16 MPa peak negative pressure. The entire procedure was guided and monitored by real-time ultrasound imaging. A total of 11 experiments were performed and preliminary results show that with suitable acoustic windows, histotripsy was able to generate a cavitation bubble cloud at the targeted fetal tissue and create mechanical tissue fractionation and removal. Morphological and histological assessment of the treated tissue confirmed that lesion locations corresponded to regions where the cavitation bubble cloud was observed. These results suggest that histotripsy has potential to become a non-invasive clinical tool for early fetal intervention on congenital anomalies such as prenatal treatment for hypoplastic left heart syndrome. |
| Starting Page | 228 |
| Ending Page | 231 |
| File Size | 12032137 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424443895 |
| ISSN | 19485727 |
| DOI | 10.1109/ULTSYM.2009.5442016 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-09-20 |
| Publisher Place | Italy |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Medical treatment Ultrasonic imaging Fractionation Acoustic pulses Clouds Pregnancy Focusing Ultrasonic transducers Abdomen Fetal heart therapeutic ultrasound fetal surgery histotripsy cavitation |
| Content Type | Text |
| Resource Type | Article |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|