NDLI: Fluorocarbon droplets as next generation contrast agents - their behavior under 1

Content Provider	IEEE Xplore Digital Library
Author	Asami, R. Azuma, T. Kawabata, K.-i.
Copyright Year	2009
Description	Author affiliation: Central Research Laboratory, Hitachi, Ltd., Tokyo, JAPAN (Asami, R.; Azuma, T.; Kawabata, K.-i.)
Abstract	Our study on fluorocarbon droplets revealed that the sensitivity of mixed-component fluorocarbon droplets to ultrasound differs with ultrasound frequency at the frequency range of 1–3 MHz. In the perfluoropentane droplets, fluorocarbon with higher boiling point is added in the droplets' core structure and ultrasonic and thermal threshold to induce phase change are compared. For all cases, adding the higher boiling point fluorocarbon increased the temperature threshold required for the phase change. The composition of the fluorocarbon droplet changed the ultrasound intensity threshold for the phase change, which corresponded with results of our previous studies done at higher frequencies. However, at 1 and 2 MHz, the amount of added higher boiling point fluorocarbon did not affect the ultrasound intensity threshold. Also, the highest magnitude of ultrasound intensity was required for a frequency of 3 MHz. For applications with lower frequency ultrasound, thermal mechanism plays a less significant role in inducing microbubbles.
Starting Page	1294
Ending Page	1297
File Size	855075
Page Count	4
File Format	PDF
ISBN	9781424443895
ISSN	19485727
DOI	10.1109/ULTSYM.2009.5442002
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-20
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Frequency Medical treatment Temperature Probes Focusing Ultrasonic transducers Thermal stresses Biomedical imaging Chemical industry fluorocarbon ultrasound contrast agent nano-droplets microbubble phase change
Content Type	Text
Resource Type	Article

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