NDLI: Real-time ultrasound elasticity imaging for liver RF ablation assessment: Preliminary ex vivo and in vivo animal studies

Content Provider	IEEE Xplore Digital Library
Author	Hua Xie Fernandez, A.T. Unmin Bae Sheng Xu Kruecker, J. Karanian, J. Chiesa, A. Pritchard, W.F. Wood, B.J.
Copyright Year	2009
Description	Author affiliation: FDA, Lab. of Cardiovascular and Interventional Therapeutics, 8401 Muirkirk Road, Laurel, MD 20708, USA (Karanian, J.; Chiesa, A.; Pritchard, W.F.) \|\| Philips Medical Systems, 22100 Bothell Everett Highway, Bothell, WA 98021, USA (Unmin Bae) \|\| Booz Allen Hamilton, One Preserve Parkway, Rockville, MD 20852, USA (Fernandez, A.T.) \|\| NIH, Clinical Center, Radiology and Imaging Sciences, Bethesda, MD 20892, USA (Wood, B.J.) \|\| Philips Research North America, 345 Scarborough Road, Briarcliff Manor, NY 10510, USA (Hua Xie; Sheng Xu; Kruecker, J.)
Abstract	In this study, a real-time compression based ultrasound elasticity imaging prototype was developed and evaluated for liver radio-frequency ablation (RFA) assessment under ex vivo and in vivo conditions. The prototype was implemented on a commercial ultrasound system (iU22, Philips Healthcare) for an L12–5 linear transducer and a C5–1 curvilinear transducer. Under the ex vivo condition, two bovine liver samples were used for L12–5 and C5–1 respectively. Under the in vivo condition, a pig was anesthetized and mechanically ventilated. Ultrasound elasticity imaging experiments were performed during breath-hold in order to reduce respiratory motion artifacts. Post-RFA strain images were compared against several imaging modalities including MRI, contrast-enhanced CT and gross pathology. For the ex vivo case, a Rita Starburst probe (AngioDynamics, Queensbury, NY) was used to perform RFA and induce tissue deformation for strain imaging. Real-time strain images were generated pre- and post-RFA. After the ablation, the liver was imaged by a Panorama 1-T MRI system (Philips Healthcare), then it was dissected along the approximate ultrasound imaging plane for lesion dimension measurement using a caliper. The post-RFA strain images depicted an ablation zone with increased stiffness that was well correlated with the physiological changes observed in the T1-weighted MR image and gross pathology. For the second ex vivo liver sample, the strain image revealed an ablation zone of 4.90 cm × 2.85 cm, and the MR image and gross pathology showed a zone of 4.56 cm × 3.24 cm and of 4.91 cm × 3.65 cm, respectively. For the in vivo study, three different commercial RFA needles were employed: the Covidien (Mansfield, MA) CoolTip single prong and triple-cluster probes, and the Rita Starburst probe. The animal underwent contrast-enhanced CT imaging immediately after RFA. It was then sacrificed and the ablated liver lobes were dissected for ex vivo MRI. All three imaging modalities showed comparable measurement of lesion dimensions. The triple-cluster Covidien probe and the Rita probe with expanding tines seemed to perform better with elasticity assessment than the Covidien single prong probe. Preliminary results from this study demonstrate that real-time ultrasound strain imaging is potentially a valuable tool for assessing liver RFA. Further technical development of this prototype will advance toward real-time clinical use.
Starting Page	139
Ending Page	142
File Size	1565042
Page Count	4
File Format	PDF
ISBN	9781424443895
ISSN	19485727
DOI	10.1109/ULTSYM.2009.5441783
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-20
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Elasticity Liver Radio frequency In vivo Animals Capacitive sensors Probes Prototypes Magnetic resonance imaging RF needle Liver RF ablation real-time ultrasound elasticity imaging strain imaging RF electrode
Content Type	Text
Resource Type	Article

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