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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Umemura, S.-i. Yoshizawa, S. Matsumoto, Y. Sasaki, K. Asami, R. Kawabata, K.-i. |
| Copyright Year | 2009 |
| Description | Author affiliation: Central Research Laboratory, Hitachi Ltd., Japan (Asami, R.; Kawabata, K.-i.) || Graduate School of Mechanical Engineering, University of Tokyo, Japan (Matsumoto, Y.) || Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Japan (Sasaki, K.) || Graduate School of Biomedical Engineering, Tohoku University, Sendai, Miyagi 980-8579, Japan (Umemura, S.-i.; Yoshizawa, S.) |
| Abstract | The bioeffect of ultrasound can be enhanced by orders of magnitude with microbubbles in a few ways. Enhancement of ultrasonic tissue absorption with a microbubble agent has been demonstrated both in theory and in an in vivo experiment. The ultrasonic power absorbed by a microbubble in its continuous wave response was numerically estimated. It has been predicted that the tissue ultrasonic absorption will be doubled when resonant microbubbles are delivered to the tissue at a concentration in the order of ten bubbles $/mm^{3}.$ An exteriorized murine kidney was exposed to focused ultrasound at 3.2 MHz. With an intravenous bolus administration of 0.2 ml/kg $Optison^{™},$ the ultrasonically induced tissue temperature elevation was multiplied by up to five times. This effect will be useful for therapeutic ultrasound if microbubbles are selectively distributed in the target tissue by ultrasound pulses focused to the tissue. Tissue selective nano-droplets which can be phasechanged to microbubbles by ultrasonic stimulation will be a key to this approach. |
| Starting Page | 93 |
| Ending Page | 100 |
| File Size | 1092274 |
| Page Count | 8 |
| File Format | |
| ISBN | 9781424443895 |
| ISSN | 19485727 |
| DOI | 10.1109/ULTSYM.2009.5441975 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-09-20 |
| Publisher Place | Italy |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Heating Ultrasonic imaging Temperature Heat engines Resonance Absorption Energy conversion Delay Biomedical engineering Mechanical engineering |
| Content Type | Text |
| Resource Type | Article |
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