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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Reznik, N. Williams, R. Burns, P.N. |
| Copyright Year | 2009 |
| Description | Author affiliation: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (Williams, R.) || Department of Medical Biophysics, University of Toronto, ON, Canada (Reznik, N.; Burns, P.N.) |
| Abstract | Submicron perfluorocarbon droplets offer a new potential ultrasound contrast agent for extravascular diagnosis. Acoustic detection is performed by vapourizing the droplet with ultrasound, converting it into a micron-sized bubble. In this study, we use optical and acoustic methods to investigate the size, stability and echogenicity of these newly created microbubbles in the first 1 s after conversion. Suspensions of droplets with mean diameter of 415 ± 20 nm were vapourized with a single 10-cycle pulse from a focused 7.5 MHz transducer. Post-conversion droplets were examined optically, with a microscope, and acoustically, with low intensity ultrasound pulses at 1.75 MHz. Optically, micron-sized bubbles with mean diameter of 1.79 ± 0.67 µm were observed as soon as 1 ms after excitation. The bubbles grew in size to a mean diameter of 6.43 ± 1.80 µm in the first 100 ms, and then stabilized in size for at least 900 ms. Acoustically, post-conversion droplets were shown to scatter ultrasound efficiently at both the fundamental and second harmonic bands and were successfully detected with pulse-inversion imaging. In the first 100 ms after conversion the scattered fundamental signal was shown to further increase, while the harmonic signal decreased before stabilizing for a time period of at least 900 ms. This characteristic acoustic behavior of post-conversion droplets may serve as a basis for the development of an ultrasound imaging technique utilizing both regular B-mode and non-linear modes for converted-droplet specific imaging. |
| Starting Page | 2778 |
| Ending Page | 2781 |
| File Size | 1322544 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424443895 |
| ISSN | 19485727 |
| DOI | 10.1109/ULTSYM.2009.5441824 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-09-20 |
| Publisher Place | Italy |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Ultrasonic imaging Optical scattering Nonlinear optics Acoustic pulses Acoustic imaging Optical imaging Acoustic signal detection Optical pulses Acoustic scattering Stability microbubbles ultraound contrast agents perfluorocarbon droplets nonlinear imaging droplet vaporization |
| Content Type | Text |
| Resource Type | Article |
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