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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Li, X. Iwai, K. Pirmoradi, F.N. Yang, C. Lin, L. |
| Copyright Year | 2015 |
| Description | Author affiliation: Mech. Eng. Dept., Univ. of California, Berkeley, Berkeley, CA, USA (Li, X.; Iwai, K.; Pirmoradi, F.N.; Yang, C.; Lin, L.) |
| Abstract | We report the development of magnetically-driven, 100μm in typical diameter, core-shell microcapsules for the on-demand and local delivery of encapsulated drug agents. These microcapsules are fabricated through a multi-stage microfluidic/optofluidic flow-focusing device with oil-based core and thermoresponsive polymer shell. In the prototype capsules, the shell structure is constructed by UV-curable polyethylene glycol diacrylate (PEGDA) with embedded 20%w/w poly N-isopropylacrylamide (PNIPAm) nanogels and 0.5%w/w magnetic iron oxide nanoparticles (10 nm in diameter). Experimentally, the releases of the oil fluorescent dye from the core of the capsules have been successfully demonstrated by remotely triggering the capsules with induction heating. As such, this drug delivery scheme could be useful for remotely-triggered, site-specific applications. |
| Starting Page | 1049 |
| Ending Page | 1052 |
| File Size | 910804 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781479989553 |
| ISSN | 21641641 |
| DOI | 10.1109/TRANSDUCERS.2015.7181106 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2015-06-21 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Drugs Nanoparticles Magnetic cores Iron Induction heating Polymers Electromagnetic heating optofluidic device Core-shell droplets drug delivery magnetic particles microfluidics |
| Content Type | Text |
| Resource Type | Article |
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