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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Decrop, D. Pardon, G. Kokalj, T. Puers, R. Haraldsson, T. Lammertyn, J. van der Wijngaart, W. |
| Copyright Year | 2015 |
| Description | Author affiliation: Dept. of Biosyst., KU Leuven, Leuven, Belgium (Decrop, D.; Kokalj, T.; Lammertyn, J.) || Dept. of Micro & Nanosyst., KTH R. Inst. of Technol., Stockholm, Sweden (Pardon, G.; Haraldsson, T.; van der Wijngaart, W.) || Dept. of Electrotech. Eng., KU Leuven, Leuven, Belgium (Puers, R.) |
| Abstract | We report a novel polymer material formulation and stamp-molding technique that enable rapid single-step manufacturing of hydrophilic-in-hydrophobic microwell arrays. We developed a modified thiol-ene-epoxy polymer (mOSTE+) formulation that mimics the surface energy of its mold during polymerization. The polymer inherits the surface energy from the mold through molecular self-assembly, in which functional monomers self-assemble at the interface between the liquid prepolymer and the mold surface. Combining this novel mOSTE+ material with a stamp-molding process leads to simultaneous surface energy mimicking and micro-structuring. This method was used to manufacture microwells with hydrophilic bottom and hydrophobic sidewall, depressed in a surrounding hydrophobic surface. The microwell arrays were successfully tested for the self-assembly of 62'000 femtoliter-droplets. Such femtoliter droplet arrays are useful for, e.g., digital ELISA and single cell/molecule analysis applications. |
| Starting Page | 514 |
| Ending Page | 517 |
| File Size | 1110375 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781479989553 |
| ISSN | 21641641 |
| DOI | 10.1109/TRANSDUCERS.2015.7180973 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2015-06-21 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Polymers Glass Fluorescence Surface treatment Self-assembly Microscopy lab-on-chip Surface energy mimicking thiol-ene-epoxy polymer OSTE (OSTE+) polymer microfluidics imprinting casting molding microwell arrays femtoliter-droplets |
| Content Type | Text |
| Resource Type | Article |
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