NDLI: CD8 T cells are essential for recovery from a respiratory vaccinia virus infection.

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CD8 T cells are essential for recovery from a respiratory vaccinia virus infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bogue, Rebecka Salek-Ardakani, Shahram Goulding, John Tahiliani, Vikas Croft, Michael
Description	Country affiliation: United States Author Affiliation: Goulding J ( Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, San Diego, CA 92037, USA.)
Abstract	The precise immune components required for protection against a respiratory Orthopoxvirus infection, such as human smallpox or monkeypox, remain to be fully identified. In this study, we used the virulent Western Reserve strain of vaccinia virus (VACV-WR) to model a primary respiratory Orthopoxvirus infection. Naive mice infected with VACV-WR mounted an early CD8 T cell response directed against dominant and subdominant VACV-WR Ags, followed by a CD4 T cell and Ig response. In contrast to other VACV-WR infection models that highlight the critical requirement for CD4 T cells and Ig, we found that only mice deficient in CD8 T cells presented with severe cachexia, pulmonary inflammation, viral dissemination, and 100% mortality. Depletion of CD8 T cells at specified times throughout infection highlighted that they perform their critical function between days 4 and 6 postinfection and that their protective requirement is critically dictated by initial viral load and virulence. Finally, the ability of adoptively transferred naive CD8 T cells to protect RAGâ »/â » mice against a lethal VACV-WR infection demonstrated that they are both necessary and sufficient in protecting against a primary VACV-WR infection of the respiratory tract.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1200799
Journal	The Journal of Immunology
Issue Number	5
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd8-positive T-lymphocytes Immunology Pathology Respiratory Tract Infections Virology Vaccinia Animals Disease Models, Animal Lung Mice Mice, Inbred C57bl Mice, Knockout Mice, Mutant Strains Recovery Of Function Mortality Severity Of Illness Index Vaccinia Virus Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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CD8 T cells use IFN-Î³ to protect against the lethal effects of a respiratory poxvirus infection.

CD8+ T cell-derived IFN-Î³ prevents infection by a second heterologous virus.

Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection.

Acute Viral Respiratory Infection Rapidly Induces a CD8+ T Cell Exhaustion-like Phenotype.

CD8 T cells utilize TRAIL to control influenza virus infection.

Extent of Systemic Spread Determines CD8+ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus.

Cutting edge: intravascular staining redefines lung CD8 T cell responses.

Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect.

Airway-Resident Memory CD8 T Cells Provide Antigen-Specific Protection against Respiratory Virus Challenge through Rapid IFN-Î³ Production.

CD8 T cells are essential for recovery from a respiratory vaccinia virus infection.

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CD8 T cells are essential for recovery from a respiratory vaccinia virus infection.