NDLI: A genetically encoded IL-1ß bioluminescence resonance energy transfer sensor to monitor inflammasome activity.

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A genetically encoded IL-1ß bioluminescence resonance energy transfer sensor to monitor inflammasome activity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Compan, Vincent Verkhratsky, Alexei Bragg, Laricia Pelegrin, Pablo Baroja-Mazo, Alberto Perroy, Julie
Description	Country affiliation: United kingdom Author Affiliation: Compan V ( Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom. vincent.compan@manchester.ac.uk)
Abstract	Inflammation is fundamental for protecting the organism against infection and injury. However, a failure to control immune response results in chronic inflammation and several associated disorders such as pain and loss of function. Initiation of inflammation is orchestrated by cytokines, among which IL-1ß is particularly important. IL-1ß is synthesized as an inactive protein that has to be processed by the inflammasome to generate the mature bioactive form. Conventional techniques cannot monitor IL-1ß activation with high spatial and temporal resolution. In this study, we present a ratiometric biosensor that allows monitoring IL-1ß processing in real time, with a temporal resolution of seconds and with a single-cell spatial resolution. Using this sensor, to our knowledge, we describe for the first time the kinetic of the inflammasome activity in living macrophages. With this new probe, we also demonstrated that the pro-IL-1ß processing occurs all over the cytoplasm.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201349
Journal	The Journal of Immunology
Issue Number	5
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Energy Transfer Immunology Inflammasomes Genetics Metabolism Interleukin-1beta Luminescent Measurements Macrophages Animals Bacterial Proteins Cell Culture Techniques Cell Line, Transformed Cell Line, Tumor Hek293 Cells Luciferases, Renilla Luminescent Proteins Mice Mice, Inbred C57bl Protein Precursors Protein Processing, Post-translational Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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