NDLI: Extent of Systemic Spread Determines CD8+ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus.

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Extent of Systemic Spread Determines CD8+ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	da Fonseca, Flávio G. Hollett, Natasha A. Flesch, Inge E. A. Quinan, Bárbara Resende Howard, Debbie Tscharke, David C. Wong, Yik Chun
Description	Author Affiliation: Flesch IE ( Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia); Hollett NA ( Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia); Wong YC ( Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia); Quinan BR ( Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia); Howard D ( John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 2601, Australia.); da Fonseca FG ( Laboratório de Virologia Básica e Aplicada, Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil); Tscharke DC ( Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia)
Abstract	CD8(+) T cells that recognize virus-derived peptides presented on MHC class I are vital antiviral effectors. Such peptides presented by any given virus vary greatly in immunogenicity, allowing them to be ranked in an immunodominance hierarchy. However, the full range of parameters that determine immunodominance and the underlying mechanisms remain unknown. In this study, we show across a range of vaccinia virus strains, including the current clonal smallpox vaccine, that the ability of a strain to spread systemically correlated with reduced immunodominance. Reduction in immunodominance was observed both in the lymphoid system and at the primary site of infection. Mechanistically, reduced immunodominance was associated with more robust priming and especially priming in the spleen. Finally, we show this is not just a property of vaccine and laboratory strains of virus, because an association between virulence and immunodominance was also observed in isolates from an outbreak of zoonotic vaccinia virus that occurred in Brazil.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1402508
Journal	The Journal of Immunology
Issue Number	5
Volume Number	195
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2015-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd8-positive T-lymphocytes Immunology Smallpox Vaccine Vaccinia Virus Vaccinia Amino Acid Sequence Animals Antigens, Viral Metabolism Virology Cell Line Epitopes, T-lymphocyte Host-pathogen Interactions Immunodominant Epitopes Interferon-gamma Mice, Inbred C57bl Species Specificity Spleen Classification Physiology Zoonoses Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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