NDLI: A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 189 Issue: 12

Year: 2012 Volume: 189 Issue: 11

Year: 2012 Volume: 189 Issue: 10

Year: 2012 Volume: 189 Issue: 9

Year: 2012 Volume: 189 Issue: 8

Year: 2012 Volume: 189 Issue: 7

Year: 2012 Volume: 189 Issue: 6

Year: 2012 Volume: 189 Issue: 5

Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.

Immune suppression and resistance mediated by constitutive activation of Wnt/ß-catenin signaling in human melanoma cells.

Anti-peptidoglycan antibodies and FcÎ³ receptors are the key mediators of inflammation in Gram-positive sepsis.

A genetically encoded IL-1ß bioluminescence resonance energy transfer sensor to monitor inflammasome activity.

The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation.

Neutrophil expression of Fas ligand and perforin directs effector CD8 T cell infiltration into antigen-challenged skin.

Acquisition of MHC:peptide complexes by dendritic cells contributes to the generation of antiviral CD8+ T cell immunity in vivo.

The bone marrow functions as the central site of proliferation for long-lived NK cells.

Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity.

CD8+CD45RA+CCR7+FOXP3+ T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells.

Negative impact of IFN-Î³ on early host immune responses to retroviral infection.

The protein tyrosine phosphatase SHP-1 regulates phagolysosome biogenesis.

Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma.

CD8 T cells are essential for recovery from a respiratory vaccinia virus infection.

A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice.

Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice.

Decoding the regulation of mast cell exocytosis by networks of Rab GTPases.

Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-ß1 signaling.

Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.

Recombinatorial biases and convergent recombination determine interindividual TCRß sharing in murine thymocytes.

B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets.

Phospholipase CÎ³2 plays a role in TCR signal transduction and T cell selection.

Dynamics of the splenic innate-like CD19â ºCD45Rlo cell population from adult mice in homeostatic and activated conditions.

CD4+ T cell-dependent IFN-Î³ production by CD8+ effector T cells in Mycobacterium tuberculosis infection.

Antibodies generated against conserved antigens expressed by bacteria and allergen-bearing fungi suppress airway disease.

Suppression of GM-CSF expression in murine and human T cells by IL-27

A common SNP in ER aminopeptidase 2 induces a specificity switch that leads to altered antigen processing

Heligmosomoides polygyrus bakeri induces tolerogenic dendritic cells that block colitis and prevent antigen-specific gut T cell responses.

Glioma big potassium channel expression in human cancers and possible T cell epitopes for their immunotherapy.

Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation.

Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat.

GB virus C envelope protein E2 inhibits TCR-induced IL-2 production and alters IL-2-signaling pathways.

Olfactomedin 4 inhibits cathepsin C-mediated protease activities, thereby modulating neutrophil killing of Staphylococcus aureus and Escherichia coli in mice.

Integrin $α_{X}β_{2}$ Is a Leukocyte Receptor for Candida albicans and Is Essential for Protection against Fungal Infections

Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase.

Nanotopography-guided migration of T cells.

Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage.

A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination.

Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia.

Stability and function of secondary Th1 memory cells are dependent on the nature of the secondary stimulus.

Prostaglandin E2 induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway.

A GpC-rich oligonucleotide acts on plasmacytoid dendritic cells to promote immune suppression.

Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention.

Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung.

The role of properdin in zymosan- and Escherichia coli-induced complement activation.

Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells.

Endothelial cells and fibroblasts amplify the arthritogenic Type I IFN response in murine Lyme Disease and are major sources of chemokines in B. burgdorferi-infected joint tissue

HUMAN H-FICOLIN INHIBITS REPLICATION OF SEASONAL AND PANDEMIC INFLUENZA A $VIRUSES^{}$

An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo.

Increased susceptibility to Salmonella infection in signal regulatory protein -deficient mice.

Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni.

Differential interaction of the two related fungal species Candida albicans and Candida dubliniensis with human neutrophils.

ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells.

VDJ recombinase-mediated TCR ß locus gene usage and coding joint processing in peripheral T cells during perinatal and pediatric development.

B cell memory to a serogroup C meningococcal conjugate vaccine in childhood and response to booster: little association with serum IgG antibody.

Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s.

CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract.

Dendritic Cell Sphingosine 1-Phosphate Receptor-3 Regulates Th1–Th2 Polarity in Kidney Ischemia–Reperfusion Injury

Airway epithelial expression of TLR5 is downregulated in healthy smokers and smokers with chronic obstructive pulmonary disease.

Systemic analysis of PPARÎ³ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity.

Rapid differentiation of monocytes into type I IFN-producing myeloid dendritic cells as an antiviral strategy against influenza virus infection.

Cutting edge: lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue.

Functional exhaustion of CD4+ T lymphocytes during primary cytomegalovirus infection.

Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production.

Noncovalent assembly of anti-dendritic cell antibodies and antigens for evoking immune responses in vitro and in vivo.

NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-Î³ and perforin-dependent mechanisms.

Year: 2012 Volume: 189 Issue: 4

Year: 2012 Volume: 189 Issue: 3

Year: 2012 Volume: 189 Issue: 2

Year: 2012 Volume: 189 Issue: 1

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Minard-Colin, Veronique Kountikov, Evgueni I. Tedder, Thomas F. Poe, Jonathan C. Haas, Karen M.
Description	Country affiliation: United States Author Affiliation: Poe JC ( Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.)
Abstract	Malignant B cells responding to external stimuli are likely to gain a growth advantage in vivo. These cells may therefore maintain surface CD19 expression to amplify transmembrane signals and promote their expansion and survival. To determine whether CD19 expression influences this process, Eµ-Myc transgenic (c-Myc(Tg)) mice that develop aggressive and lethal B cell lymphomas were made CD19 deficient (c-Myc(Tg)CD19â »/â »). Compared with c-Myc(Tg) and c-Myc(Tg)CD19â º/â » littermates, the median life span of c-Myc(Tg)CD19â »/â » mice was prolonged by 81-83% (p < 0.0001). c-Myc(Tg)CD19â »/â » mice also lived 42% longer than c-Myc(Tg) littermates following lymphoma detection (p < 0.01). Tumor cells in c-Myc(Tg) and c-Myc(Tg)CD19â »/â » mice were B lineage derived, had a similar phenotype with a large blastlike appearance, invaded multiple lymphoid tissues, and were lethal when adoptively transferred into normal recipient mice. Importantly, reduced lymphomagenesis in c-Myc(Tg)CD19â »/â » mice was not due to reductions in early B cell numbers prior to disease onset. In mechanistic studies, constitutive c-Myc expression enhanced CD19 expression and phosphorylation on active sites. Reciprocally, CD19 expression in c-Myc(Tg) B cells enhanced c-Myc phosphorylation at regulatory sites, sustained higher c-Myc protein levels, and maintained a balance of cyclin D2 expression over that of cyclin D3. These findings define a new and novel c-Myc:CD19 regulatory loop that positively influences B cell transformation and lymphoma progression.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201000
Journal	The Journal of Immunology
Issue Number	5
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Cd19 Genetics Lymphoma, B-cell Immunology Pathology Proto-oncogene Proteins C-myc Signal Transduction Animals Metabolism Physiology B-lymphocyte Subsets Disease Progression Lymphocyte Activation Mice Mice, Inbred C57bl Mice, Knockout Mice, Transgenic Nucleic Acid Amplification Techniques Biosynthesis Survival Analysis Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in