NDLI: Functional exhaustion of CD4+ T lymphocytes during primary cytomegalovirus infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Donner, Catherine Lecomte, Sandra Olislagers, Véronique Liesnard, Corinne Huygens, Ariane Marchant, Arnaud Antoine, Pierre
Description	Country affiliation: Belgium Author Affiliation: Antoine P ( Institute for Medical Immunology, Université Libre de Bruxelles, 6041 Charleroi, Belgium.)
Abstract	Human CMV establishes lifelong persistence after primary infection. Chronic CMV infection is associated with intermittent viral reactivation inducing high frequencies of CD4+ T lymphocytes with potent antiviral and helper properties. Primary CMV infection is characterized by an intense viral replication lasting for several months. The impact of this prolonged exposure to high Ag loads on the functionality of CD4+ T cells remains incompletely understood. In pregnant women with primary CMV infection, we observed that CMV-specific CD4+ T lymphocytes had a decreased capacity to proliferate and to produce IL-2. A very large proportion of CMV-specific CD4+ T cells had downregulated the expression of CD28, a costimulatory molecule centrally involved in the production of IL-2. Unexpectedly, both CD28+ and CD28+ CD4+ T cells produced low levels of IL-2. This defective production of IL-2 was part of a larger downregulation of cytokine production. Indeed, CMV-specific CD4+ T cells produced lower amounts of IFN-Î³ and TNF- and showed lower functional avidity during primary as compared with chronic infection. Increased programmed death-1 expression was observed in CD28+ CMV-specific CD4+ T cells, and programmed death-1 inhibition increased proliferative responses. These results indicate that primary CMV infection is associated with the exhaustion of CMV-specific CD4+ T cells displaying low functional avidity for viral Ags.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	5
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd4-positive T-lymphocytes Immunology Virology Cytomegalovirus Infections Pathology Lymphopenia Cells, Cultured Chronic Disease Cytomegalovirus Growth & Development Lymphocyte Activation Lymphocyte Depletion Pregnancy Virus Replication Clinical Trial Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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