NDLI: Phospholipase CÎ³2 plays a role in TCR signal transduction and T cell selection.

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Phospholipase CÎ³2 plays a role in TCR signal transduction and T cell selection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wen, Renren Chen, Yuhong Wang, Demin Fu, Guoping Schuman, James
Description	Country affiliation: United States Author Affiliation: Fu G ( Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226, USA.)
Abstract	One of the important signaling events following TCR engagement is activation of phospholipase CÎ³ (PLCÎ³). PLCÎ³ has two isoforms, PLCÎ³1 and PLCÎ³2. It is known that PLCÎ³1 is important for TCR signaling and TCR-mediated T cell selection and functions, whereas PLCÎ³2 is critical for BCR signal transduction and BCR-mediated B cell maturation and functions. In this study, we report that PLCÎ³2 was expressed in primary T cells, and became associated with linker for activated T cells and Src homology 2-domain containing leukocyte protein of 76 kDa and activated upon TCR stimulation. PLCÎ³1/PLCÎ³2 double-deficient T cells displayed further block from CD4 and CD8 double-positive to single-positive transition compared with PLCÎ³1 single-deficient T cells. TCR-mediated proliferation was further impaired in PLCÎ³1/PLCÎ³2 double-deficient T cells compared with PLCÎ³1 single-deficient T cells. TCR-mediated signal transduction, including Ca²â º mobilization and Erk activation, was further impaired in PLCÎ³1/PLCÎ³2 double-deficient relative to PLCÎ³1 single-deficient T cells. In addition, in HY TCR transgenic mouse model, thymic positive and negative selections were reduced in PLCÎ³1 heterozygous- and PLCÎ³2 homozygous-deficient (PLCÎ³1â º/â »PLCÎ³2â »/â ») relative to wild-type, PLCÎ³2 single-deficient (PLCÎ³2â »/â »), or PLCÎ³1 heterozygous-deficient (PLCÎ³1â º/â ») mice. Taken together, these data demonstrate that PLCÎ³2 participates in TCR signal transduction and plays a role in T cell selection.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1103458
Journal	The Journal of Immunology
Issue Number	5
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Phospholipase C Gamma Physiology Receptors, Antigen, T-cell Signal Transduction Immunology Thymus Gland Enzymology Animals Cell Differentiation Genetics Cells, Cultured Mice Mice, Inbred C57bl Mice, Knockout Mice, Transgenic Deficiency Primary Cell Culture Cytology Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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