NDLI: B cell memory to a serogroup C meningococcal conjugate vaccine in childhood and response to booster: little association with serum IgG antibody.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jin, Celina Perrett, Kirsten P. Yu, Ly-Mee Pollard, Andrew J. Clutterbuck, Elizabeth Winter, Amy P. Curtis, Nigel John, Tessa M. Kibwana, Elizabeth
Description	Country affiliation: United kingdom Author Affiliation: Perrett KP ( Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford OX3 7LE, United Kingdom. kirsten.perrett@rch.org.au)
Abstract	The maintenance of adequate serum Ab levels following immunization has been identified as the most important mechanism for individual long-term protection against rapidly invading encapsulated bacteria. The mechanisms for maintaining adequate serum Ab levels and the relationship between Ag-specific memory B cells and Ab at steady state are poorly understood. We measured the frequency of circulating serogroup C meningococcal (MenC)-specific memory B cells in 250 healthy 6- to 12-y-old children 6 y following MenC conjugate vaccine priming, before a booster of a combined Haemophilus influenzae type b-MenC conjugate vaccine and then 1 wk, 1 mo, and 1 y after the booster. We investigated the relationship between circulating MenC-specific memory B cell frequencies and Ab at baseline and following the booster vaccine. We found very low frequencies of circulating MenC-specific memory B cells at steady state in primary school-aged children and little association with MenC IgG Ab levels. Following vaccination, there were robust memory B cell booster responses that, unlike Ab levels, were not dependent on age at priming with MenC. Measurement of B cell memory in peripheral blood does not predict steady state Ab levels nor the capacity to respond to a booster dose of MenC Ag.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	5
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies, Bacterial Blood B-lymphocyte Subsets Immunology Immunization, Secondary Immunoglobulin G Immunologic Memory Meningococcal Vaccines Administration & Dosage Neisseria Meningitidis, Serogroup C Biosynthesis Microbiology Clinical Trials, Phase Iv As Topic Haemophilus Vaccines Vaccines, Combined Vaccines, Conjugate Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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