NDLI: Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni.

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Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni.

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Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Heikema, Astrid P. Crocker, Paul R. Lewis, Leanne E. Oetke, Cornelia Klaas, Mariliis Easton, Alistair Willison, Hugh J. Erwig, Lars P.
Description	Country affiliation: United kingdom Author Affiliation: Klaas M ( Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.)
Abstract	Sialoadhesin (Sn) is a macrophage (Mφ)-restricted receptor that recognizes sialylated ligands on host cells and pathogens. Although Sn is thought to be important in cellular interactions of Mφs with cells of the immune system, the functional consequences of pathogen engagement by Sn are unclear. As a model system, we have investigated the role of Sn in Mφ interactions with heat-killed Campylobacter jejuni expressing a GD1a-like, sialylated glycan. Compared to Sn-expressing bone marrow-derived macrophages (BMDM) from wild-type mice, BMDM from mice either deficient in Sn or expressing a non-glycan-binding form of Sn showed greatly reduced phagocytosis of sialylated C. jejuni. This was accompanied by a strong reduction in MyD88-dependent secretion of TNF- , IL-6, IL-12, and IL-10. In vivo studies demonstrated that functional Sn was required for rapid TNF- and IFN-ß responses to i.v.-injected sialylated C. jejuni. Bacteria were captured within minutes after i.v. injection and were associated with Mφs in both liver and spleen. In the spleen, IFN-ß-reactive cells were localized to Snâ º Mφs and other cells in the red pulp and marginal zone. Together, these studies demonstrate that Sn plays a key role in capturing sialylated pathogens and promoting rapid proinflammatory cytokine and type I IFN responses.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1200776
Journal	The Journal of Immunology
Issue Number	5
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Campylobacter Jejuni Immunology Pathogenicity Inflammation Mediators Metabolism Interferon Type I Physiology Membrane Glycoproteins Receptors, Immunologic Sialoglycoproteins Animals Bone Marrow Cells Cells, Cultured Gene Knock-in Techniques Host-pathogen Interactions Mice Mice, 129 Strain Mice, Inbred Balb C Mice, Inbred C57bl Mice, Knockout Sialic Acid Binding Ig-like Lectin 1 Time Factors Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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