NDLI: Cutting edge: intravascular staining redefines lung CD8 T cell responses.

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Cutting edge: intravascular staining redefines lung CD8 T cell responses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lefrancois, Leo Deisinger, Angela Masopust, David Anderson, Kristin G. Sung, Heungsup Skon, Cara N. Vezys, Vaiva
Description	Country affiliation: United States Author Affiliation: Anderson KG ( Department of Microbiology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.)
Abstract	Nonlymphoid T cell populations control local infections and contribute to inflammatory diseases, thus driving efforts to understand the regulation of their migration, differentiation, and maintenance. Numerous observations indicate that T cell trafficking and differentiation within the lung are starkly different from what has been described in most nonlymphoid tissues, including intestine and skin. After systemic infection, we found that >95% of memory CD8 T cells isolated from mouse lung via standard methods were actually confined to the pulmonary vasculature, despite perfusion. A respiratory route of challenge increased virus-specific T cell localization within lung tissue, although only transiently. Removing blood-borne cells from analysis by the simple technique of intravascular staining revealed distinct phenotypic signatures and chemokine-dependent trafficking restricted to Ag-experienced T cells. These results precipitate a revised model for pulmonary T cell trafficking and differentiation and a re-evaluation of studies examining the contributions of pulmonary T cells to protection and disease.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201682
Journal	The Journal of Immunology
Issue Number	6
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd8-positive T-lymphocytes Immunology Pathology Capillaries Lung Blood Supply Animals Antibodies Administration & Dosage Antigens, Cd8 Transplantation Virology Cell Movement Genetics Metabolism Lymphocytic Choriomeningitis Mice Mice, Inbred C57bl Mice, Mutant Strains Pertussis Toxin Pneumonia, Viral Spleen Staining And Labeling Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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