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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Phelps, Jamie Lomonossoff, George P. Soto, Carissa M. Johnson, John E. Dressick, Walter J. Meshcheriakova, Yulia Griva, Igor Lebedev, Nikolai |
| Description | Country affiliation: United kingdom Author Affiliation: Lebedev N ( Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, 4555 Overlook Avenue SW, Code 6900, Washington DC 20375, USA); Griva I ( Department of Mathematical Sciences and Computational Material Science Center, George Mason University, 4400 University Drive, Fairfax, VA 22030, USA); Dressick WJ ( Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, 4555 Overlook Avenue SW, Code 6900, Washington DC 20375, USA); Phelps J ( Department of Molecular Biology,The Scripps Research Institute, 10550, North Torrey Pines Road, La Jolla, California 92037, USA); Johnson JE ( Department of Molecular Biology,The Scripps Research Institute, 10550, North Torrey Pines Road, La Jolla, California 92037, USA); Meshcheriakova Y ( Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, 4555 Overlook Avenue SW, Code 6900, Washington DC 20375, USA); Lomonossoff GP ( Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, 4555 Overlook Avenue SW, Code 6900, Washington DC 20375, USA); Soto CM ( Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, 4555 Overlook Avenue SW, Code 6900, Washington DC 20375, USA) |
| Abstract | Fabrication of nanoscale structures with localized surface plasmons allows for substantial increase in sensitivity of chem/bio sensors. The main challenge for realizing complex nanoplasmonic structures in solution is the high level of precision required at the nanoscale to position metal nanoparticles in 3D. In this study, we report a virus-like particle (VLP) for building a 3D plasmonic nanostructure in solution in which gold nanoparticles are precisely positioned on the VLP by directed self-assembly techniques. These structures allow for concentration of electromagnetic fields in the desired locations between the gold nanoparticles or 'hot spots'. We measure the efficiency of the optical field spatial concentration for the first time, which results in a ten-fold enhancement of the capsid Raman peaks. Our experimental results agree with our 3D finite element simulations. Furthermore, we demonstrate as a proof-of-principle that the plasmonic nanostructures can be utilized in DNA detection down to 0.25 ng/µl (lowest concentration tested), while the protein peaks from the interior of the nanoplasmonic structures, potentially, can serve as an internal tracer for the biosensors. |
| ISSN | 09565663 |
| Volume Number | 77 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-03-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Dna Analysis Genetics Metal Nanoparticles Chemistry Spectrum Analysis, Raman Instrumentation Surface Plasmon Resonance Virion Ultrastructure Biosensing Techniques Equipment Design Equipment Failure Analysis Gold Nanotechnology Printing, Three-dimensional Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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