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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sung, Jong Hwan Kim, Donghyun Choi, Jong-Ryul Song, Hyerin Kim, Kyujung |
| Description | Author Affiliation: Choi JR ( Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), 701-310 Daegu, Republic of Korea.); Song H ( Department of Cogno-Mechatronics Engineering, Pusan National University, 609-735 Busan, Republic of Korea.); Sung JH ( Department of Chemical Engineering, Hongik University, 121-791 Seoul, Republic of Korea. Electronic address: jhsung22@hongik.ac.kr.); Kim D ( School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea, 120-749, Republic of Korea.); Kim K ( Department of Cogno-Mechatronics Engineering, Pusan National University, 609-735 Busan, Republic of Korea) |
| Abstract | Since the early 2000s, microfluidic cell culture systems have attracted significant attention as a promising alternative to conventional cell culture methods and the importance of designing an efficient detection system to analyze cell behavior on a chip in real time is raised. For this reason, various measurement techniques for microfluidic devices have been developed with the development of microfluidic assays for high-throughput screening and mimicking of in vivo conditions. In this review, we discuss optical measurement techniques for microfluidic assays. First of all, the recent development of fluorescence- and absorbance-based optical measurement systems is described. Next, advanced optical detection systems are introduced with respect to three emphases: 1) optimization for long-term, real-time, and in situ measurements; 2) performance improvements; and 3) multimodal analysis conjugations. Moreover, we explore presents future prospects for the establishment of optical detection systems following the development of complex, multi-dimensional microfluidic cell culture assays to mimic in vivo tissue, organ, and human systems. |
| ISSN | 09565663 |
| Volume Number | 77 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-03-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Instrumentation Cell Separation Flow Injection Analysis Lab-on-a-chip Devices Optical Devices Tissue Array Analysis Animals Equipment Design Equipment Failure Analysis Humans Journal Article Research Support, Non-u.s. Gov't Review Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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