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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Narayan, Raj K. Hartings, Jed A. Limnuson, Kanokwan Wu, Zhizhen Amin, Aseer Li, Chunyan Ahn, Chong H. Narayan, Anjali Golanov, Eugene V. |
| Description | Author Affiliation: Li C ( Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA); Limnuson K ( Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA.); Wu Z ( Microsystem and BioMEMS Laboratory, University of Cincinnati, Cincinnati, OH 45221, USA.); Amin A ( Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA.); Narayan A ( Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY 11549, USA.); Golanov EV ( Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA.); Ahn CH ( Microsystem and BioMEMS Laboratory, University of Cincinnati, Cincinnati, OH 45221, USA.); Hartings JA ( Department of Neurosurgery, University of Cincinnati (UC) Neuroscience Institute, UC College of Medicine, Cincinnati, OH 45219, USA.); Narayan RK ( Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA) |
| Abstract | We report a novel single neural probe for real-time simultaneous monitoring of multiple neurochemicals and direct-current electrocorticography (DC-ECoG). A major advance of this probe is the inclusion of two iridium oxide reference electrodes to improve sensor accuracy. The ECoG reference electrode is identical to the ECoG recording electrodes to significantly improve DC stability, while the reference for electrochemical sensors has 10-fold lower polarization rate to minimize the small current-induced drift in the reference electrode potential. In vitro, the single probe selectively measured oxygen (r(2)=0.985 ± 0.01, concentration range=0-60 mmHg, limit of detection=0.4 ± 0.07 mmHg) and glucose (r(2)=0.989 ± 0.009, concentration range=0-4mM, limit of detection=31 ± 8 µM) in a linear fashion. The performance of the single probe was assessed in an in vivo needle prick model to mimic sequelae of traumatic brain injury. It successfully monitored the theoretically expected transient brain oxygen, glucose, and DC potential changes during the passage of spreading depolarization (SD) waves. We envision that the developed probe can be used to decipher the cause-effect relationships between multiple variables of brain pathophysiology with the high temporal and spatial resolutions that it provides. |
| ISSN | 09565663 |
| Volume Number | 77 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-03-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Action Potentials Physiology Electrocorticography Instrumentation Electrodes, Implanted Microelectrodes Nerve Tissue Proteins Metabolism Parietal Lobe Animals Computer Systems Conductometry Equipment Design Equipment Failure Analysis Male Neurochemistry Cytology Rats Rats, Sprague-dawley Journal Article Research Support, U.s. Gov't, Non-p.h.s. Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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