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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Ying Liu, Qiao Yuan, Zheng Mao, Chang-Jie Liu, Xing-Pei Zhang, Sheng-Yi Niu, He-Lin Jin, Bao-Kang |
| Description | Author Affiliation: Yang Y ( School of Chemistry and Chemical Engineering, Anhui University, Hefei 230039, PR China.); Yuan Z ( School of Chemistry and Chemical Engineering, Anhui University, Hefei 230039, PR China.); Liu XP ( School of Chemistry and Chemical Engineering, Anhui University, Hefei 230039, PR China.); Liu Q ( School of Chemistry and Chemical Engineering, Anhui University, Hefei 230039, PR China.); Mao CJ ( School of Chemistry and Chemical Engineering, Anhui University, Hefei 230039, PR China. Electronic address: maochangjie@sina.com.); Niu HL ( School of Chemistry and Chemical Engineering, Anhui University, Hefei 230039, PR China.); Jin BK ( School of Chemistry and Chemical Engineering, Anhui University, Hefei 230039, PR China.); Zhang SY ( School of Chemistry and Chemical Engineering, Anhui University, Hefei 230039, PR China.) |
| Abstract | The detection and speciation analysis of metal-ion is very important for environmental monitoring. A novel electrochemical biosensor for Nickel(II) detection based on a DNAzyme-CdSe nanocomposite was developed. We firstly hybridized with capture probe (DNA1) and sequentially with DNA (DNA2) on the gold electrode. Then CdSe QDs were incorporated the specific recognition of DNA2 by covalent assembling. Upon addition of nickel ion into the above system, the substrate strand of the immobilized DNAzyme was catalytically cleaved by target Ni(2+), resulting in disassociation of the shorter DNA fragments containing CdSe QDs. The remaining CdSe QDs on the electrode surface detected by differential pulse anodic stripping voltammetry (DPASV). Under optimal conditions, the as-prepared sensor exhibited high sensitivity and fast response to Ni(2+) with the linear range from 20 nM to 0.2mM and a low detection limit of 6.67 nM. The prepared biosensor also shows good stability and good reproducibility and high selectivity toward target Ni(2+) against other metal ions because of highly specific Ni(2+)-dependent DNAzyme. Thus, our strategy has a good potential in the environment surveys. |
| ISSN | 09565663 |
| Volume Number | 77 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-03-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cadmium Compounds Chemistry Conductometry Instrumentation Dna, Catalytic Nanocomposites Nickel Analysis Selenium Compounds Water Pollutants, Chemical Biosensing Techniques Environmental Monitoring Enzymes, Immobilized Equipment Design Equipment Failure Analysis Ultrastructure Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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