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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cui, Xiaoqiang Singh, D. J. Zheng, Weitao Wang, Haitao Guan, Weiming Qi, Kun Wang, Qiyu Xue, Tianyu Liu, Chang |
| Description | Author Affiliation: Xue T ( Key Laboratory of Automobile Materials of MOE and State Key Laboratory of Superhard Materials, Department of Materials Science, Jilin University, Changchun 130012, People׳s Republic of China.); Cui X ( Key Laboratory of Automobile Materials of MOE and State Key Laboratory of Superhard Materials, Department of Materials Science, Jilin University, Changchun 130012, People׳s Republic of China. Electronic address: xqcui@jlu.edu.cn.); Guan W ( State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming 650106, People׳s Republic of China.); Wang Q ( Key Laboratory of Automobile Materials of MOE and State Key Laboratory of Superhard Materials, Department of Materials Science, Jilin University, Changchun 130012, People׳s Republic of China.); Liu C ( Key Laboratory of Automobile Materials of MOE and State Key Laboratory of Superhard Materials, Department of Materials Science, Jilin University, Changchun 130012, People׳s Republic of China.); Wang H ( Key Laboratory of Automobile Materials of MOE and State Key Laboratory of Superhard Materials, Department of Materials Science, Jilin University, Changchun 130012, People׳s Republic of China.); Qi K ( Key Laboratory of Automobile Materials of MOE and State Key Laboratory of Superhard Materials, Department of Materials Science, Jilin University, Changchun 130012, People׳s Republic of China.); Singh DJ ( Materials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6056, United States.); Zheng W ( Key Laboratory of Automobile Materials of MOE and State Key Laboratory of Superhard Materials, Department of Materials Science, Jilin University, Changchun 130012, People׳s Republic of China. Electronic address: wtzheng@jlu.edu.cn.) |
| Abstract | The binding of DNA with graphene oxide (GO) is important for applications in disease diagnosis, genetic screening, and drug discovery. The standard assay methods are mainly limited to indirect observation via fluorescence labeling. Here we report the use of surface plasmon resonance for direct sensing of DNA/GO binding. We show that this can be used for ultra-sensitive detection of single-stranded DNA (ssDNA). Furthermore, the results provide a more direct probe of DNA/GO binding abilities and confirm that hydrogen bonding plays a key role in the interaction between GO and ssDNA. This enables to a novel biosensor for highly sensitive and selective detection of ssDNA based on indirect competitive inhibition assay (ICIA). We report development of such a sensor with a linear dynamic range of 10(-14)-10(-6)M, a detection limit of 10fM and a high level of stability during repeated regeneration. |
| ISSN | 09565663 |
| Volume Number | 58 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-08-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Instrumentation Dna Analysis Chemistry Graphite Molecular Probe Techniques Surface Plasmon Resonance Equipment Design Equipment Failure Analysis Gold Metal Nanoparticles Ultrastructure Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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