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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Weng, Francis L. Balaraman, Vasanthi Wu, Geru |
| Description | Author Affiliation: Wu G ( Department of Internal Medicine Residency Program, St. Barnabas Medical Center, Livingston, New Jersey, USA.) |
| Abstract | Tacrolimus is an immunosuppressant frequently used following solid organ transplantation, including renal transplantation. Peripheral neuropathy is an uncommon neurological side effect of tacrolimus and has rarely been reported in renal transplantation. We report a patient who received a living-related donor kidney transplant and presented with altered mental status and new-onset bilateral foot drop. Laboratory tests including cerebrospinal fluid tests excluded infection, and MRI of the brain showed chronic microvascular ischaemic changes. Electromyography and nerve conduction study confirmed bilateral common peroneal nerve demyelination. He was also found to have inadvertently overdosed on tacrolimus at home. After switching from tacrolimus to cyclosporine, the patient's symptoms improved within 5 months. His renal function was maintained with an immunosuppressant regimen of cyclosporine, prednisone and mycophenolic acid. The prompt recognition of tacrolimus as a potential neurotoxic drug in a patient with renal transplant and substituting tacrolimus with a different immunosuppressant may prevent permanent neurological damage. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2013 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Brain Diseases Chemically Induced Immunosuppressive Agents Adverse Effects Kidney Transplantation Polyneuropathies Tacrolimus Diagnosis Diagnosis, Differential Electromyography Neural Conduction Risk Factors Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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