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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kass, Jonathan Rafferty, William Boujaoude, Ziad Dammert, Pedro |
| Description | Author Affiliation: Dammert P ( Department of Pulmonary and Critical care Medicine, Cooper University Hospital, Camden, New Jersey, USA. pedrodammert@hotmail.com) |
| Abstract | A 78-year-old man was diagnosed with bladder carcinoma in situ and was successfully treated with intravesical bacillus Calmette-Guérin (BCG) instillations. At 6 months after the last dose, he developed fever, weight loss and malaise. He had an extensive negative workup at an outside hospital and was treated empirically with ciprofloxacin for 2 weeks. The fever resolved but returned months later and he was readmitted with pancytopenia, elevated alkaline phosphatase and ground glass opacities on the chest CT. Bone marrow and liver biopsies showed non-caseating granulomas and were negative for acid-fast bacillus (AFB) and fungal stains. Mycobacterium tuberculosis complex PCR of the bone marrow was negative. Owing to the high clinical suspicion of disseminated BCG infection, the patient was treated empirically. After 9 weeks of incubation, the bone marrow AFB culture grew Mycobacterium bovis. Within 2 months of treatment his symptoms resolved and his laboratory results normalised. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2013 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | BCG Vaccine Adverse Effects Fever Of Unknown Origin Etiology Mycobacterium Bovis Isolation & Purification Pancytopenia Tuberculosis Chemically Induced Administration, Intravesical Antitubercular Agents Therapeutic Use Administration & Dosage Bone Marrow Microbiology Diagnosis, Differential Polymerase Chain Reaction Tomography, X-Ray Computed Drug Therapy Urinary Bladder Neoplasms Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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