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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vargas, Maria Isabel Chofflon, Michel Kamtchum Tatuene, Joseph Burkhardt, Karim |
| Description | Author Affiliation: Kamtchum Tatuene J ( Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland. jkamtchum@yahoo.fr) |
| Abstract | A 75-year-old woman with unremarkable medical history, consulted for a 5-month history of involuntary shaking of left upper limb. Clinical examination revealed polyminimyoclonus of the upper limbs with cogwheel-like rigidity, hyperreflexia, bradykinesia, inconstant spastic-like rigidity in the lower limbs and a stiff and cautious gait. These symptoms, together with the memory impairment found on neuropsychological assessment yielded suspicion for a subacute encephalopathy probably due to a non-conventional infectious agent. There was no 14-3-3 protein found in the cerebrospinal fluid and no periodic sharp wave complexes on EEG. These findings made the diagnosis of Creutzfeldt-Jakob disease (CJD) rather unlikely according to the current WHO diagnostic criteria. However, typical isolated cortical hyperintensity of right temporal, parietal and occipital lobes on MRI suggested a probable CJD and prompted cerebral biopsy which confirmed the diagnosis. This article emphasises the need to update the current WHO criteria by including radiological findings. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2013 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Cerebral Cortex Creutzfeldt-Jakob Syndrome Diagnosis 14-3-3 Proteins Cerebrospinal Fluid Biopsy Pathology Electroencephalography Magnetic Resonance Imaging Sensitivity And Specificity World Health Organization Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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