NDLI: Prevalence of renal dysfunction in tacrolimus-treated pediatric transplant recipients: a systematic review.

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Prevalence of renal dysfunction in tacrolimus-treated pediatric transplant recipients: a systematic review.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gijsen, Violette M. G. J. Hesselink, Dennis A. Croes, Kenneth Koren, Gideon de Wildt, Saskia N.
Description	Country affiliation: Netherlands Author Affiliation: Gijsen VM ( Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.)
Abstract	Renal dysfunction after non-renal transplantation in adult tacrolimus-treated transplant patients is well documented. Little is known about its prevalence in children. Age-related changes in both disposition and effect of tacrolimus as well as renal function may preclude extrapolation of adult data to children. To systematically review the literature on renal dysfunction in non-renal pediatric transplant recipients treated with tacrolimus. PubMed/Medline, Embase, and Google were searched from their inception until April 19, 2012, with the search terms 'tacrolimus,' 'renal function,' 'transplantation,' and 'children.' Eighteen of 385 retrieved papers were considered relevant. Twelve dealt with liver, four with heart transplant, one with heart and lung transplant, and one with intestinal recipients. Reported prevalences of mild and severe chronic kidney disease ranged from 0% to 39% and 0% to 71.4%, respectively, for liver, and from 22.7% to 40% and 6.8% to 46%, respectively, for heart and/or lung transplant recipients. Ranges remained wide after adjusting for follow-up time and disease severity. Possible explanations are inclusion bias and definitions used for renal dysfunction. A considerable proportion of pediatric non-renal transplant patients who receive tacrolimus-based immunosuppression, appear to suffer from chronic kidney disease. This conclusion warrants further research into the real risk, its risk factors, and individualization of immunosuppressant therapy.
File Format	HTM / HTML
ISSN	13973142
Issue Number	3
Volume Number	17
e-ISSN	13993046
Journal	Pediatric Transplantation
Language	English
Publisher	Wiley
Publisher Date	2013-05-01
Publisher Place	Denmark
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation Discipline Pediatrics Immunosuppressive Agents Adverse Effects Kidney Diseases Chemically Induced Organ Transplantation Methods Tacrolimus Child Humans Complications Epidemiology Prevalence Risk Factors Time Factors Treatment Outcome Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Transplantation Pediatrics, Perinatology and Child Health

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