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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Meiller, Ralph Bachmann, Björn O. Kruse, Friedrich E. Wessel, Julia M. |
| Description | Author Affiliation: Wessel JM ( Department of Ophthalmology, University of Erlangen, Erlangen, Germany. julia.wessel@uk-erlangen.de) |
| Abstract | A 39-year-old male patient underwent uncomplicated deep anterior lamellar keratoplasty due to keratoconus. On day 5 after surgery, small whitish infiltrates developed in the corneal interface. The diagnosis of fungal keratitis was made when the culture medium of the graft grew Candida after the surgical intervention. Despite intensive antimycotic treatment and irrigation of the interface, the infiltrates persisted and eventually enlarged. Therefore, revision surgery with penetrating keratoplasty was performed. Microbiological analysis showed Candida orthopsilosis in the culture of the excised graft button. Histopathological staining of the excised graft showed periodic acid-Schiff-positive and Grocott methenamine silver-positive clusters of yeast between Descemet's membrane and the deep corneal stroma with focal perforations through Descemet's membrane. The treatment of mycotic keratitis caused by C orthopsilosis is challenging. Antimycotic treatment was unsuccessful in this case. Progression of the keratitis and perforation of Descemet's membrane suggest that early surgical intervention by penetrating keratoplasty is required. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2013 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Candida Isolation & Purification Cornea Microbiology Corneal Transplantation Adverse Effects Eye Infections, Fungal Etiology Keratitis Surgical Wound Infection Pathology Surgery Diagnosis, Differential Diagnosis Keratoconus Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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