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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dave, Shruti D. Vanikar, Aruna V. Trivedi, Hargovind L. |
| Description | Author Affiliation: Dave SD ( Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G R Doshi and K M Mehta Institute of Kidney Diseases & Research Centre (IKDRC)-Dr H L Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, Gujarat, India.) |
| Abstract | Type 1 diabetes mellitus (T1DM) is a common cause of end-stage renal disease (ESRD). Various factors contribute to wide fluctuations in blood glucose levels and exogenous insulin requirement in such patients even after renal transplantation (RT). Simultaneous pancreas-kidney transplantation is one of the therapies for these patients. Stem cell (SC) therapy for T1DM and for minimisation of immunosuppression after RT has shown encouraging results. We report a 30-year-old-man with T1DM since 15 years and ESRD since 2 years, who underwent living donor RT and co-infusion of in vitro generated insulin-making cells differentiated from donor adipose tissue derived mesenchymal stem cells and bone marrow -derived haematopoietic SC into subcutaneous tissue, portal and thymic circulation under non-myeloablative conditioning. Over follow-up of 13 months he has stable graft function with serum creatinine, 1.2 mg/dl, zero rejection and glycosylated haemoglobin level of 6.1% on calcineurin-inhibitor based therapy. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2013 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Diabetes Mellitus, Type 1 Therapy Hematopoietic Stem Cell Transplantation Insulin-Secreting Cells Transplantation Kidney Failure, Chronic Surgery Kidney Transplantation Mesenchymal Stem Cell Transplantation Adipose Tissue Cytology Cell Differentiation Mesenchymal Stromal Cells Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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