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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mak, Vincent Salam, Amr King, Christopher Orhan, Orhan |
| Description | Author Affiliation: Salam A ( Department of Respiratory Medicine, Central Middlesex Hospital, North West London Hospitals NHS Trust, London, UK. amrsalam@nhs.net) |
| Abstract | Pulmonary embolism (PE) is a common and life-threatening condition. The British Thoracic Society PE guidelines state that PE is reliably excluded in patients with low-intermediate clinical probability and a negative D-dimer. We are reporting the case of a 47-year-old lady, taking tranexamic acid for menorrhagia, who presented with shortness of breath and was diagnosed with extensive bilateral PE. She had a low clinical risk of PE as determined by her Wells score, and a subsequent negative D-dimer. This patient's D-dimer value of 15 ng/ml (HemosIL DD HS assay) was the lowest associated with any CT pulmonary angiogram (n=1645) recorded at our trust over a 2-year period. This lady was successfully treated with a heparin infusion and warfarin. No further thromboembolic events had occurred by 18-month follow-up. To our knowledge, this is the first case report to describe tranexamic acid causing an extremely low false-negative D-dimer masking PE. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2013 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Pulmonary Embolism Diagnosis Tranexamic Acid Adverse Effects Anticoagulants Therapeutic Use False Negative Reactions Fibrin Fibrinogen Degradation Products Heparin Administration & Dosage Infusions, Intravenous Menorrhagia Drug Therapy Blood Tomography, X-Ray Computed Warfarin Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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