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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dave, Shruti D. Vanikar, Aruna V. Thakkar, Umang G. Trivedi, Hargovind L. |
| Description | Author Affiliation: Trivedi HL ( Department of Nephrology and Transplantation Medicine, G R Doshi and K M Mehta Institute of Kidney Diseases and Research Centre (IKDRC)-Dr H L Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, Gujarat, India. ikdrcad1@sancharnet.in) |
| Abstract | The authors report a 17-year-female and a 19-year-male with uncontrolled insulin-dependent diabetes mellitus (IDDM) for ≥10 years, treated with insulin-secreting human adipose tissue derived mesenchymal stem cells (IS-h-ADMSC). Both had hypothyroidism and were diagnosed as polyglandular autoimmune syndrome type-3 (PGAS-3). PGAS are rare polyendocrinopathies with ≥2 endocrine disorders mediated by autoimmune mechanisms leading to hypo-function and organ failure. Therapeutic options are hormone replacement, immunosuppression and avoiding infection. The authors administered autologous H-AD-IS-MSC+bone marrow-derived haematopoietic stem cells (HSC) into portal circulation with conditioning of cyclophosphamide, bortezomib, rituximab and rabbit-antithymoglobulin. Over follow-up of 38 and 16 months, respectively, both are doing well with sustained fall of glycosylated haemoglobin (Hb1Ac) from 8.1 to 6.4% and 14.2 to 8.6%, respectively and C-peptide raised from 0.01 to 0.23 ng/ml and 0.1 to 0.34 ng/ml, respectively with sustained 40% decreased insulin requirement. Thus long-term control of IDDM in PGAS-3 with co-transplantation of H-AD-IS-MSC+HSC can be achieved safely and effectively. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2011 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Hematopoietic Stem Cell Transplantation Insulin Secretion Mesenchymal Stem Cell Transplantation Polyendocrinopathies, Autoimmune Surgery Adolescent Diabetes Mellitus, Type 1 Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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