NDLI: Exposure-response modeling of flow-mediated dilation provides an unbiased and informative measure of endothelial function.

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Exposure-response modeling of flow-mediated dilation provides an unbiased and informative measure of endothelial function.

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Exposure-response modeling of flow-mediated dilation provides an unbiased and informative measure of endothelial function.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Van Brackle, Charles Henry Harris, Ryan A. Hallow, Karen Melissa
Description	Author Affiliation: Van Brackle CH ( University of Georgia.); Harris RA ( Augusta University-Georgia.); Hallow KM ( University of Georgia hallowkm@uga.edu.)
Abstract	The brachial artery flow-mediated dilation (FMD) test is the most widely utilized, method to evaluate endothelial function non-invasively in humans by calculating the percent change in diameter (FMD%). However, the underutilized velocity and diameter time-course data coupled with confounding influences in shear exposure, noise, and upward bias make the FMD test less desirable. In this study, we developed an exposure-response model-based approach that not only quantifies FMD based on the rich velocity and diameter data, it overcomes previously acknowledged challenges. FMD data were obtained from 15 apparently healthy participants, each exposed to 4 different cuff occlusion durations. The velocity response following cuff release was described by an exponential model with two parameters defining peak velocity and rate of decay. Shear exposure derived from velocity was used to drive the diameter response model, which consists of additive constriction and dilation terms. Three parameters describing distinct aspects of the vascular response to shear (magnitude of the initial constriction response, and magnitude and time constant of the dilation response) were estimated for both the individuals and population. These parameters are independent of shear exposure. Thus, this approach produces identifiable and physiologically meaningful parameters that may provide additional information for comparing differences between experimental groups or over time, and provides a means to completely account for shear exposure.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Language	English
Publisher	American Physiological Society
Publisher Date	2016-12-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Applied Physiology Molecular Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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