NDLI: ADRENODEMEDULLATION ACTIVATES THE Ca2+-DEPENDENT PROTEOLYSIS IN SOLEUS MUSCLES FROM RATS EXPOSED TO COLD.

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ADRENODEMEDULLATION ACTIVATES THE Ca2+-DEPENDENT PROTEOLYSIS IN SOLEUS MUSCLES FROM RATS EXPOSED TO COLD.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Manfredi, Leandro H. Lustrino, D. Machado, Juliano Silveira, Wilian Assis Zanon, Neusa Maria Navegantes, Luiz C. Kettelhut, Isis do Carmo
Description	Author Affiliation: Manfredi LH ( Federal University of Fronteira Sul.); Lustrino D ( University of São Paulo, Ribeirão Preto Medical School.); Machado J ( University of São Paulo, Ribeirão Preto Medical School.); Silveira WA ( University of São Paulo, Ribeirão Preto Medical School.); Zanon NM ( School of Medicine of Ribeirao Preto.); Navegantes LC ( University of São Paulo, Ribeirão Preto Medical School.); Kettelhut ID ( University of São Paulo idckette@fmrp.usp.br.)
Abstract	Previous studies have shown that catecholamines in vivo and in vitro inhibit the activity of Ca -dependent proteolysis in skeletal muscles under basal conditions. In the present study we sought to investigate the role of catecholamines in regulating the Ca -dependent proteolysis in soleus and extensor digitorum longus (EDL) muscles from rats acutely exposed to cold. Overall proteolysis, the activity of proteolytic systems as well as protein levels and gene expression of different components of calpain system were investigated in rats submitted to adrenodemedullation (ADMX) and exposed to cold for 24 h. ADMX drastically reduced plasma epinephrine and promoted an additional increase in the overall proteolysis, which was already increased by cold exposure. The rise in the rate of protein degradation in soleus muscles from adrenodemedullated cold-exposed rats was due to the high activity of the Ca -dependent proteolysis, which was associated with the generation of a 145-kDa cleaved -fodrin fragment, a typical calpain substrate, and lower protein levels and mRNA expression of calpastatin, the endogenous calpain inhibitor. Unlike that observed for soleus muscles, the cold-induced muscle proteolysis in EDL was not affected by ADMX. In isolated soleus muscle, clenbuterol, a selective ß -adrenoceptor agonist reduced the basal Ca -dependent proteolysis and completely abolished the activation of this pathway by the cholinergic agonist carbachol. These data suggest that catecholamines released from the adrenal medulla inhibit cold-induced protein breakdown in soleus, and this anti-proteolytic effect on the Ca -dependent proteolytic system is apparently mediated through activation of calpastatin, which leads to suppression of calpain activation.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Language	English
Publisher	American Physiological Society
Publisher Date	2016-10-20
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Applied Physiology Molecular Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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