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A pilot study examining the impact of exercise training on skeletal muscle genes related to the TLR signaling pathway in older adults following hip fracture.

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A pilot study examining the impact of exercise training on skeletal muscle genes related to the TLR signaling pathway in older adults following hip fracture.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	McKenzie, Alec I. Briggs, Robert A. Barrows, Katherine M. Nelson, Daniel S. Kwon, Oh Sung Hopkins, Paul N. Higgins, Thomas F. Marcus, Robin L. Drummond, Micah J.
Description	Author Affiliation: McKenzie AI ( University of Utah.); Briggs RA ( University of Utah.); Barrows KM ( University of Utah.); Nelson DS ( University of Utah.); Kwon OS ( University of Utah.); Hopkins PN ( University of Utah.); Higgins TF ( University of Utah.); Marcus RL ( University of Utah.); Drummond MJ ( University of Utah micah.drummond@hsc.utah.edu.)
Abstract	Older adults after hip fracture surgery experience progressive muscle atrophy and weakness limiting full recovery. Further understanding of the molecular mechanisms in muscle with adaptation to exercise training in this vulnerable population is necessary. Therefore, we conducted a pilot study to investigate the skeletal muscle inflammatory and ceramide biosynthesis gene expression levels associated with the toll-like receptor (TLR) pathway before (Pre) and following a 3-month multi-component exercise training program in older adults (3M, 4F; 78.4 ± 13.3y; 25.5 ± 2.3 kg/m ) ~4 months after repair from hip fracture (HipFx). Vastus lateralis biopsies from the surgical limb were obtained before (Pre) and after training. Molecular endpoints and muscle function data were also compared to matched non-exercise healthy controls (CON). As a follow-up analysis, we evaluated specific sphingolipid pools in HipFx and CON muscle. Following training, quadriceps cross sectional area, strength and 6-minute walk (6MW) increased in the surgical limb (P<0.05). Additionally, MYD88, TAK1, NFKB1, IL6, SPT2, and CERS1 gene expression decreased after training (P≤0.05) but some remained elevated above CON levels. Interestingly, MYD88 mRNA was inversely correlated to quadriceps CSA, strength and 6MW. Finally, muscle dihydroceramides and phosphoceramides in HipFx were lower than CON at Pre (P≤0.05) but after training differences from CON were removed. Together, our pilot data support that exercise training alters skeletal muscle inflammation and ceramide metabolism associated with TLR signaling in older adults recovering from hip fracture surgery and may be related to improvements in muscle function recovery.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Language	English
Publisher	American Physiological Society
Publisher Date	2016-10-27
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Applied Physiology Molecular Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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