NDLI: A LED-based phosphorimeter for measurement of microcirculatory oxygen pressure.

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A LED-based phosphorimeter for measurement of microcirculatory oxygen pressure.

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A LED-based phosphorimeter for measurement of microcirculatory oxygen pressure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guerci, Philippe Ince, Yasin Heeman, Paul Faber, Dirk J. Ergin, Bulent Ince, Can
Description	Author Affiliation: Guerci P ( Academic Medical Center, University of Amsterdam phil.guerci@gmail.com.); Ince Y ( Academic Medical Center, University of Amsterdam.); Heeman P ( Academic Medical Center, University of Amsterdam.); Faber DJ ( Academic Medical Center.); Ergin B ( Academic Medical Center.); Ince C ( Academic Medical Center, University of Amsterdam.)
Abstract	Quantitative measurements of microcirculatory and tissue oxygenation are of prime importance in experimental research. Non-invasive time-resolved quenching of phosphorescence has given further insight into the fundamental mechanisms of oxygen transport to healthy tissues and in models of disease. Phosphorimeters are devices dedicated to the study of phosphorescence quenching. The experimental applications of phosphorimeters range from measuring a specific oxygen partial pressure (PO ) in cellular organelles such as mitochondria, finding values of PO distributed over an organ or capillaries, to measuring microcirculatory PO changes simultaneously in several organ systems. Most of the current phosphorimeters use flash lamps as a light excitation source. However, a major drawback of flash lamps is their inherent plasma glow that persists for tens of microseconds after the primary discharge. This complex distributed excitation pattern generated by the flash lamp can lead to inaccurate PO readings unless a deconvolution analysis is performed. Using light-emitting diode (LED), a rectangular shaped light pulse can be generated that provides a more uniformly distributed excitation signal. This study presents the design and calibration process of an LED-based phosphorimeter (LED-P). The in vitro calibration of the LED-P using Palladium(II)-meso-tetra(4-carboxyphenyl)-porphyrin (Pd-TCCP) as a phosphorescent dye is presented. The pH and temperature were altered to assess whether the decay times of the Pd-TCCP measured by the LED-P were significantly influenced. An in vivo validation experiment was undertaken to measure renal cortical PO in a rat subjected to hypoxic ventilation conditions and ischemia/reperfusion. The benefits of using LEDs as a light excitation source are presented.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Language	English
Publisher	American Physiological Society
Publisher Date	2016-12-08
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Applied Physiology Molecular Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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