NDLI: Vascular function and Endothelin-1: Tipping the Balance between Vasodilation and Vasoconstriction.

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Vascular function and Endothelin-1: Tipping the Balance between Vasodilation and Vasoconstriction.

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Vascular function and Endothelin-1: Tipping the Balance between Vasodilation and Vasoconstriction.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nishiyama, Steven K. Zhao, Jia Wray, D. Walter Richardson, Russell S.
Description	Author Affiliation: Nishiyama SK ( Touro University 1College of Osteopathic Medicine.); Zhao J ( University of Utah.); Wray DW ( University of Utah.); Richardson RS ( University of Utah r.richardson@hsc.utah.edu.)
Abstract	Endothelin-1 (ET-1), a potent vasoconstrictor secreted by vascular endothelial cells, has been implicated in the pathophysiology of numerous cardiovascular diseases, yet the direct impact of ET-1 on vascular function remains unclear. Therefore, in seven young (23 ± 1 years) healthy subjects, we investigated the effect of an intra-arterial infusion of ET-1 on reactive hyperemia (RH) and flow-mediated dilation (FMD) in the popliteal artery following 5-min of suprasystolic cuff occlusion. ET-1 infusion significantly attenuated basal leg blood flow (Control: 62 ± 4 ml/min, ET-1: 47 ± 9 ml/min), RH (area-under-curve, AUC) (Control: 162 ± 15 ml, ET-1: 104 ± 16 ml), and peak RH (Control: 572 ± 51 ml/min, ET-1: 412 ± 32 ml/min) (P < 0.05). Administration of ET-1 also reduced FMD (Control: 2.4 ± 0.3 %, ET-1: 0.5 ± 0.5 %) and FMD normalized for shear rate (Control: 10.5 × 10 ± 2.0 ×10 %/s , ET-1: 0.9 × 10 ± 2.8 × 10 %/s ). These findings reveal that elevated levels of ET-1 have a significant impact on vascular function, indicating that studies employing RH and FMD as markers of microvascular function and nitric oxide (NO) bioavailability, respectively, should exercise caution, as ET-1 can impact these assessments by tipping the balance between vasodilation and vasoconstriction, in favor of the latter.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Language	English
Publisher	American Physiological Society
Publisher Date	2016-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Applied Physiology Molecular Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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