NDLI: SINGLE PASSIVE LEG MOVEMENT INDUCED-HYPEREMIA: A SIMPLE VASCULAR FUNCTION ASSESSMENT WITHOUT A CHRONOTROPIC RESPONSE.

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SINGLE PASSIVE LEG MOVEMENT INDUCED-HYPEREMIA: A SIMPLE VASCULAR FUNCTION ASSESSMENT WITHOUT A CHRONOTROPIC RESPONSE.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Venturelli, Massimo Layec, Gwenael Trinity, Joel D. Hart, Corey R. Broxterman, Ryan M. Richardson, Russell S.
Description	Author Affiliation: Venturelli M ( University of Milan Massimo.venturelli@unimi.it.); Layec G ( University of Utah.); Trinity JD ( University of Utah.); Hart CR ( University of Utah.); Broxterman RM ( University of Utah.); Richardson RS ( University of Utah.)
Abstract	Passive leg movement (PLM)-induced hyperemia is a novel approach to assess vascular function, with a potential clinical role. However, in some instances, the varying chronotropic response induced by PLM has been proposed to be a potentially confounding factor. Therefore, we simplified and modified the PLM model to require just a single PLM (sPLM), an approach which may evoke a peripheral hemodynamic response, allowing a vascular function assessment, but at the same time minimizing central responses. To both characterize and assess the utility of sPLM, in 12 healthy subjects, we measured heart rate (HR), stroke volume (SV), cardiac output (CO), mean arterial pressure (MAP), leg blood flow (LBF), and calculated leg vascular conductance (LVC) during both standard PLM, consisting of passive knee flexion and extension performed at 1 Hz for 60 s, and sPLM, consisting of only a single passive knee flexion and extension over 1 second. During PLM, MAP transiently decreased (5±1 mmHg) while both HR and CO increased from baseline (6.0±1.1 bpm, and 0.8 ±0.01 l/min, respectively). Following sPLM, MAP fell similarly (5±2 mmHg; p=0.8), but neither HR nor CO responses were identifiable. The peak LBF and LVC response was similar for PLM (993±189 ml/min; 11.9±1.5 ml/min/mmHg, respectively) and sPLM (878±119 ml/min; 10.9±1.6 ml/min/mmHg, respectively). Thus, sPLM represents a variant of the PLM approach to assess vascular function that is more easily performed and evokes a peripheral stimulus that induces a significant hyperemia, but does not generate a, potentially confounding, chronotropic response, which may make sPLM more useful clinically.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Language	English
Publisher	American Physiological Society
Publisher Date	2016-11-10
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Applied Physiology Molecular Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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