NDLI: Trans-spinal direct current stimulation modulates migration and proliferation of adult newly-born spinal cells in mice.

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Trans-spinal direct current stimulation modulates migration and proliferation of adult newly-born spinal cells in mice.

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Trans-spinal direct current stimulation modulates migration and proliferation of adult newly-born spinal cells in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Samaddar, Sreyashi Vazquez, Kizzy Ponika, Dipen Toruno, Pedro Sahbani, Karim Begum, Sultana Abouelela, Ahmed Mekhael, Wagdy Ahmed, Zaghloul
Description	Author Affiliation: Samaddar S ( College of Staten Island for Developmental Neuroscience.); Vazquez K ( College of Staten Island for Developmental Neuroscience.); Ponika D ( College of Staten Island for Developmental Neuroscience.); Toruno P ( The College of Staten Island.); Sahbani K ( The College of Staten Island for Developmental Neuroscience.); Begum S ( College of Staten Island for Developmental Neurocience.); Abouelela A ( College of Staten Island for Developmental Neuroscience.); Mekhael W ( The College of Staten Island.); Ahmed Z ( The College of Staten Island zaghloul.ahmed@csi.cuny.edu.)
Abstract	Direct current electrical fields have been shown to be a major factor in the regulation of cell proliferation, differentiation, migration, and survival, as well as in the maturation of dividing cells during development. During adulthood, spinal cord cells are continuously produced in both animals and humans, and they hold great potential for neural restoration following spinal cord injury. While the effects of direct current electrical fields on adult-born spinal cells cultured ex vivo have recently been reported, the effects of direct current electrical fields on adult-born spinal cells in vivo have not been characterized. Here, we provide convincing findings that a therapeutic form of trans-spinal direct current stimulation (tsDCS) effects the migration and proliferation of adult-born spinal cells in mice. Specifically, cathodal-tsDCS attracted the adult-born spinal cells, while anodal-tsDCS repulsed them. In addition, both tsDCS polarities caused a significant increase in cell number. Regarding the potential mechanisms involved, both cathodal- and anodal-tsDCS caused significant increases in expression of brain-derived neurotrophic factor (BDNF), while expression of nerve growth factor (NGF) increased and decreased, respectively. In the spinal cord, both anodal and cathodal tsDCS increased blood flow. Since blood flow and angiogenesis are associated with the proliferation of neural stem cells, increased blood flow may represent a major factor in the modulation of newly-born spinal cells by tsDCS. Consequently, we propose that the method and novel findings presented in the current study have the potential to facilitate cellular, molecular, and/or bioengineering strategies to repair injured spinal cords.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Language	English
Publisher	American Physiological Society
Publisher Date	2016-12-08
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Applied Physiology Molecular Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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