NDLI: Skeletal muscle power and fatigue at the tolerable limit of ramp-incremental exercise in COPD.

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Skeletal muscle power and fatigue at the tolerable limit of ramp-incremental exercise in COPD.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cannon, Daniel T. Coelho, Ana Claudia Cao, Robert Cheng, Andrew Porszasz, Janos Casaburi, Richard Rossiter, Harry B.
Description	Author Affiliation: Cannon DT ( Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center.); Coelho AC ( Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center.); Cao R ( Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center.); Cheng A ( Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center.); Porszasz J ( Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center.); Casaburi R ( Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center.); Rossiter HB ( Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center hrossiter@ucla.edu.)
Abstract	Muscle fatigue (a reduced power for a given activation) is common following exercise in COPD. Whether muscle fatigue, and reduced maximal voluntary locomotor power, are sufficient to limit whole-body exercise in COPD is unknown. We hypothesized in COPD: 1) exercise is terminated with a locomotor muscle power reserve; 2) reduction in maximal locomotor power is related to ventilatory limitation; and 3) muscle fatigue at intolerance is less than age-matched controls. We used a rapid switch from hyperbolic to isokinetic cycling to measure the decline in peak isokinetic power at the limit of incremental exercise ('performance fatigue') in 13 COPD (FEV 49±17 %pred) and 12 controls. By establishing the baseline relationship between muscle activity and isokinetic power, we apportioned performance fatigue into the reduction in muscle activation and muscle fatigue. Peak isokinetic power at intolerance was ~130% of peak incremental power in controls (274±73 vs 212±84W, p<0.05), but ~260% in COPD (187±141 vs 72±34W, p<0.05) - greater than controls (p<0.05). Muscle fatigue as a fraction of baseline peak isokinetic power was not different in COPD vs controls (0.11±0.20 vs 0.19±0.11). Baseline to intolerance, the median frequency of maximal isokinetic muscle activity was unchanged in COPD but reduced in controls (+4.3±11.6 vs -5.5±7.6%, p<0.05). Performance fatigue as a fraction of peak incremental power was greater in COPD vs controls and related to resting (FEV /FVC) and peak exercise (VÌ /MVV) pulmonary function (r =0.47, r =0.55, p<0.05). COPD patients are more fatigable than controls, but this fatigue is insufficient to constrain locomotor power and define exercise intolerance.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Language	English
Publisher	American Physiological Society
Publisher Date	2016-09-22
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Applied Physiology Molecular Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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