NDLI: Aberrant Glycosylation as Biomarker for Cancer: Focus on CD43

Content Provider	PubMed Central
Author	Tuccillo, Franca Maria De Laurentiis, Annamaria Palmieri, Camillo Fiume, Giuseppe Bonelli, Patrizia Borrelli, Antonella Tassone, Pierfrancesco Scala, Iris Buonaguro, Franco Maria Quinto, Ileana Scala, Giuseppe
Copyright Year	2014
Abstract	Glycosylation is a posttranslational modification of proteins playing a major role in cell signalling, immune recognition, and cell-cell interaction because of their glycan branches conferring structure variability and binding specificity to lectin ligands. Aberrant expression of glycan structures as well as occurrence of truncated structures, precursors, or novel structures of glycan may affect ligand-receptor interactions and thus interfere with regulation of cell adhesion, migration, and proliferation. Indeed, aberrant glycosylation represents a hallmark of cancer, reflecting cancer-specific changes in glycan biosynthesis pathways such as the altered expression of glycosyltransferases and glycosidases. Most studies have been carried out to identify changes in serum glycan structures. In most cancers, fucosylation and sialylation are significantly modified. Thus, aberrations in glycan structures can be used as targets to improve existing serum cancer biomarkers. The ability to distinguish differences in the glycosylation of proteins between cancer and control patients emphasizes glycobiology as a promising field for potential biomarker identification. In this review, we discuss the aberrant protein glycosylation associated with human cancer and the identification of protein glycoforms as cancer biomarkers. In particular, we will focus on the aberrant CD43 glycosylation as cancer biomarker and the potential to exploit the UN1 monoclonal antibody (UN1 mAb) to identify aberrant CD43 glycoforms.
Related Links	http://dx.doi.org/10.1155/2014/742831
Starting Page	742831
File Format	PDF
ISSN	23146133
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2014
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2014-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Identification of MicroRNAs as Potential Biomarker for Gastric Cancer by System Biological Analysis

Glycosylation-Based Serum Biomarkers for Cancer Diagnostics and Prognostics

Flower protein: biomarker for early cancer detection?

B-Cell Activating Factor as a Cancer Biomarker and Its Implications in Cancer-Related Cachexia

Biomarker and Translational Prostate Cancer Research

Cytoglobin as a Biomarker in Cancer: Potential Perspective for Diagnosis and Management

RUNX2: a prognostic biomarker for triple-negative breast cancer?

Aberrant RNA splicing and its functional consequences in cancer cells

Early Second-Trimester Serum MicroRNAs as Potential Biomarker for Nondiabetic Macrosomia

Aberrant Glycosylation as Biomarker for Cancer: Focus on CD43

Similar Documents

Identification of MicroRNAs as Potential Biomarker for Gastric Cancer by System Biological Analysis

Glycosylation-Based Serum Biomarkers for Cancer Diagnostics and Prognostics

Flower protein: biomarker for early cancer detection?

B-Cell Activating Factor as a Cancer Biomarker and Its Implications in Cancer-Related Cachexia

Biomarker and Translational Prostate Cancer Research

Cytoglobin as a Biomarker in Cancer: Potential Perspective for Diagnosis and Management

RUNX2: a prognostic biomarker for triple-negative breast cancer?

Aberrant RNA splicing and its functional consequences in cancer cells

Early Second-Trimester Serum MicroRNAs as Potential Biomarker for Nondiabetic Macrosomia

Aberrant Glycosylation as Biomarker for Cancer: Focus on CD43