NDLI: IL-6 Impairs Myogenic Differentiation by Downmodulation of p90RSK/eEF2 and mTOR/p70S6K Axes, without Affecting AKT Activity

Content Provider	PubMed Central
Author	Pelosi, Michele Rossi, Manuela De Barberi, Laura Antonio, Musarò
Copyright Year	2014
Abstract	IL-6 is a multifaceted pleiotropic cytokine, which is produced by a variety of cell types and targets different cells and tissues.In physiological conditions, IL-6 can be locally and transiently produced by skeletal muscle and plays an important role in muscle homeostasis.Circulating IL-6 levels are normally very low or undetectable but are dramatically increased in several pathologic conditions.In this study, we aimed to define the potential molecular mechanisms underlying the effects of IL-6 on myogenic program.We explored the molecular mechanisms through which exogenous IL-6,or the conditioned medium from the murine C-26 adenocarcinoma cells (a cellular model that secretes high levels of IL-6 and induces cancer cachexia in mice),interferes with the myogenic program.Our study revealed that IL-6 induces the activation of the Stat3 signaling and promotes the downmodulation of the p90RSK/eEF2 and mTOR/p70S6K axes,while it does not affect the activation of AKT. We thus identified potential molecular mediators of the inhibitory effects of IL-6 on myogenic program.
Related Links	http://dx.doi.org/10.1155/2014/206026
Starting Page	206026
File Format	PDF
ISSN	23146133
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2014
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2014-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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