NDLI: Microsurgical Techniques Used to Construct the Vascularized and Neurotized Tissue Engineered Bone

Content Provider	PubMed Central
Author	Fan, Junjun Long, Bi Jin, Dan Wei, Kuanhai Chen, Bin Zhang, Zhiyong Pei, Guoxian
Copyright Year	2014
Abstract	The lack of vascularization in the tissue engineered bone results in poor survival and ossification. Tissue engineered bone can be wrapped in the soft tissue flaps which are rich in blood supply to complete the vascularization in vivo by microsurgical technique, and the surface of the bone graft can be invaded with new vascular network. The intrinsic vascularization can be induced via a blood vessel or an arteriovenous loop located centrally in the bone graft by microsurgical technique. The peripheral nerve especially peptidergic nerve has effect on the bone regeneration. The peptidergic nerve can be used to construct the neurotized tissue engineered bone by implanting the nerve fiber into the center of bone graft. Thus, constructing a highly vascularized and neurotized tissue engineered bone according with the theory of biomimetics has become a useful method for repairing the large bone defect. Many researchers have used the microsurgical techniques to enhance the vascularization and neurotization of tissue engineered bone and to get a better osteogenesis effect. This review aims to summarize the microsurgical techniques mostly used to construct the vascularized and neurotized tissue engineered bone.
Related Links	http://dx.doi.org/10.1155/2014/281872
Starting Page	281872
File Format	PDF
ISSN	23146133
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2014
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2014-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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Comment on “Microsurgical Techniques Used to Construct the Vascularized and Neurotized Tissue Engineered Bone”

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Correction: Mandibular reconstruction using an axially vascularized tissue-engineered construct

Microsurgical Techniques Used to Construct the Vascularized and Neurotized Tissue Engineered Bone

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Comment on “Microsurgical Techniques Used to Construct the Vascularized and Neurotized Tissue Engineered Bone”

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