NDLI: The Dopaminergic Reward System and Leisure Time Exercise Behavior: A Candidate Allele Study

Content Provider	PubMed Central
Author	Huppertz, Charlotte Bartels, Meike Groen-blokhuis, Maria M. Dolan, Conor V. Moor, Marleen H. M. De Abdellaoui, Abdel Van, Beijsterveldt Catharina E. M. Ehli, Erik A. Hottenga, Jouke-jan Willemsen, Gonneke Xiao, Xiangjun Paul, Scheet Davies, Gareth E. Boomsma, Dorret I. Hudziak, James J. Geus, Eco J. C. De
Copyright Year	2014
Abstract	Purpose. Twin studies provide evidence that genetic influences contribute strongly to individual differences in exercise behavior. We hypothesize that part of this heritability is explained by genetic variation in the dopaminergic reward system. Eight single nucleotide polymorphisms (SNPs in DRD1: rs265981, DRD2: rs6275, rs1800497, DRD3: rs6280, DRD4: rs1800955, DBH: rs1611115, rs2519152, and in COMT: rs4680) and three variable number of tandem repeats (VNTRs in DRD4, upstream of DRD5, and in DAT1) were investigated for an association with regular leisure time exercise behavior. Materials and Methods. Data on exercise activities and at least one SNP/VNTR were available for 8,768 individuals aged 7 to 50 years old that were part of the Netherlands Twin Register. Exercise behavior was quantified as weekly metabolic equivalents of task (MET) spent on exercise activities. Mixed models were fitted in SPSS with genetic relatedness as a random effect. Results. None of the genetic variants were associated with exercise behavior (P > .02), despite sufficient power to detect small effects. Discussion and Conclusions. We did not confirm that allelic variants involved in dopaminergic function play a role in creating individual differences in exercise behavior. A plea is made for large genome-wide association studies to unravel the genetic pathways that affect this health-enhancing behavior.
Related Links	http://dx.doi.org/10.1155/2014/591717
Starting Page	591717
File Format	PDF
ISSN	23146133
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2014
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2014-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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