NDLI: Antibodies in the Pathogenesis of Hypertension

Content Provider	PubMed Central
Author	Chan, Christopher T. Lieu, Maggie Toh, Ban-hock Kyaw, Tin S. Bobik, Alexander Sobey, Christopher G. Drummond, Grant R.
Copyright Year	2014
Abstract	It has long been known that circulating levels of IgG and IgM antibodies are elevated in patients with essential and pregnancy-related hypertension. Recent studies indicate these antibodies target, and in many cases activate, G-protein coupled receptors and ion channels. Prominent among these protein targets are AT1 receptors, α 1-adrenoceptors, β 1-adrenoceptors, and L-type voltage operated Ca2+ channels, all of which are known to play key roles in the regulation of blood pressure through modulation of vascular tone, cardiac output, and/or Na+/water reabsorption in the kidneys. This suggests that elevated antibody production may be a causal mechanism in at least some cases of hypertension. In this brief review, we will further describe the protein targets of the antibodies that are elevated in individuals with essential and pregnancy-related hypertension and the likely pathophysiological consequences of antibody binding to these targets. We will speculate on the potential mechanisms that underlie elevated antibody levels in hypertensive individuals and, finally, we will outline the therapeutic opportunities that could arise with a better understanding of how and why antibodies are produced in hypertension.
Related Links	http://dx.doi.org/10.1155/2014/504045
Starting Page	504045
File Format	PDF
ISSN	23146141
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2014
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2014-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Molecular Pathogenesis of Anti-NMDAR Encephalitis

The role of enterocyte defects in the pathogenesis of congenital diarrheal disorders

Helicobacter pylori and Pathogenesis

Molecular Mechanisms Involved in the Pathogenesis of Alphavirus-Induced Arthritis

Anticardiolipin antibodies and renovascular hypertension.

Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis

The Characteristics of Thrombin in Osteoarthritic Pathogenesis and Treatment

Sepsis: Pathogenesis, Biomarkers, and Treatment

Idiopathic pulmonary arterial hypertension

Antibodies in the Pathogenesis of Hypertension

Similar Documents

Molecular Pathogenesis of Anti-NMDAR Encephalitis

The role of enterocyte defects in the pathogenesis of congenital diarrheal disorders

Helicobacter pylori and Pathogenesis

Molecular Mechanisms Involved in the Pathogenesis of Alphavirus-Induced Arthritis

Anticardiolipin antibodies and renovascular hypertension.

Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis

The Characteristics of Thrombin in Osteoarthritic Pathogenesis and Treatment

Sepsis: Pathogenesis, Biomarkers, and Treatment

Idiopathic pulmonary arterial hypertension

Antibodies in the Pathogenesis of Hypertension