NDLI: B-Cell Activating Factor as a Cancer Biomarker and Its Implications in Cancer-Related Cachexia

Content Provider	PubMed Central
Author	Michal, Rihacek Julie, Bienertova-vasku Dalibor, Valik Sterba, Jaroslav Katerina, Pilatova Lenka, Zdrazilova-dubska
Copyright Year	2015
Abstract	B-cell activating factor (BAFF) is a cytokine and adipokine of the TNF ligand superfamily. The main biological function of BAFF in maintaining the maturation of B-cells to plasma cells has recently made it a target of the first FDA-approved selective BAFF antibody, belimumab, for the therapy of systemic lupus erythematosus. Concomitantly, the role of BAFF in cancer has been a subject of research since its discovery. Here we review BAFF as a biomarker of malignant disease activity and prognostic factor in B-cell derived malignancies such as multiple myeloma. Moreover, anti-BAFF therapy seems to be a promising approach in treatment of B-cell derived leukemias/lymphomas. In nonhematologic solid tumors, BAFF may contribute to cancer progression by mechanisms both dependent on and independent of BAFF's proinflammatory role. We also describe ongoing research into the pathophysiological link between BAFF and cancer-related cachexia. BAFF has been shown to contribute to inflammation and insulin resistance which are known to worsen cancer cachexia syndrome. Taking all the above together, BAFF is emerging as a biomarker of several malignancies and a possible hallmark of cancer cachexia.
Related Links	http://dx.doi.org/10.1155/2015/792187
Starting Page	792187
File Format	PDF
ISSN	23146133
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2015
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2015-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

B-Cell Activating Factor as a Cancer Biomarker and Its Implications in Cancer-Related Cachexia.

miR-155 as a Biomarker in B-Cell Malignancies

Imbalance of the Nerve Growth Factor and Its Precursor as a Potential Biomarker for Diabetic Retinopathy

InACTIVatINg cancer cachexia

Exhaled Nitric Oxide as a Biomarker in COPD and Related Comorbidities

Inflammation Based Regulation of Cancer Cachexia

Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination

Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology

Functional and metabolic impairments in cancer cachexia

B-Cell Activating Factor as a Cancer Biomarker and Its Implications in Cancer-Related Cachexia

Similar Documents

B-Cell Activating Factor as a Cancer Biomarker and Its Implications in Cancer-Related Cachexia.

miR-155 as a Biomarker in B-Cell Malignancies

Imbalance of the Nerve Growth Factor and Its Precursor as a Potential Biomarker for Diabetic Retinopathy

InACTIVatINg cancer cachexia

Exhaled Nitric Oxide as a Biomarker in COPD and Related Comorbidities

Inflammation Based Regulation of Cancer Cachexia

Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination

Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology

Functional and metabolic impairments in cancer cachexia

B-Cell Activating Factor as a Cancer Biomarker and Its Implications in Cancer-Related Cachexia