NDLI: Pomegranate Fruit as a Rich Source of Biologically Active Compounds

Content Provider	PubMed Central
Author	Sreekumar, Sreeja Hima, Sithul Muraleedharan, Parvathy Azeez, Juberiya Md. Sreeharshan, Sreeja
Copyright Year	2014
Abstract	Pomegranate is a widely used plant having medicinal properties. In this review, we have mainly focused on the already published data from our laboratory pertaining to the effect of methanol extract of pericarp of pomegranate (PME) and have compared it with other relevant literatures on Punica. Earlier, we had shown its antiproliferative effect using human breast (MCF-7, MDA MB-231), and endometrial (HEC-1A), cervical (SiHa, HeLa), and ovarian (SKOV3) cancer cell lines, and normal breast fibroblasts (MCF-10A) at concentration of 20–320 μ g/mL. The expressions of selected estrogen responsive genes (PR, pS2, and C-Myc) were downregulated by PME. Unlike estradiol, PME did not increase the uterine weight and proliferation in bilaterally ovariectomized Swiss-Albino mice models and its cardioprotective effects were comparable to that of 17 β -estradiol. We had further assessed the protective role of PME on skeletal system, using MC3T3-E1 cells.The results indicated that PME (80 μ g/mL) significantly increased ALP(Alkaline Phosphatase) activity, supporting its suggested role in modulating osteoblastic cell differentiation.The antiosteoporotic potential of PME was also evaluated in ovariectomized (OVX) rodent model.The results from our studies and from various other studies support the fact that pomegranate fruit is indeed a source of biologically active compounds.
Related Links	http://dx.doi.org/10.1155/2014/686921
Starting Page	686921
File Format	PDF
ISSN	23146133
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2014
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2014-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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