NDLI: Beta-Catenin and Epithelial Tumors: A Study Based on 374 Oropharyngeal Cancers

Content Provider	PubMed Central
Author	Santoro, Angela Pannone, Giuseppe Papagerakis, Silvana Mcguff, H. Stan Cafarelli, Barbara Lepore, Silvia Maria, Salvatore De Rubini, Corrado Mattoni, Marilena Staibano, Stefania Mezza, Ernesto Rosa, Gaetano De Aquino, Gabriella Losito, Simona Loreto, Carla Crimi, Salvatore Pantaleo, Bufo Muzio, Lorenzo Lo
Copyright Year	2014
Abstract	Introduction. Although altered regulation of the Wnt pathway via beta-catenin is a frequent event in several human cancers, its potential implications in oral/oropharyngeal squamous cell carcinomas (OSCC/OPSCC) are largely unexplored. Work purpose was to define association between beta-catenin expression and clinical-pathological parameters in 374 OSCCs/OP-SCCs by immunohistochemistry (IHC). Materials and Methods. Association between IHC detected patterns of protein expression and clinical-pathological parameters was assessed by statistical analysis and survival rates by Kaplan-Meier curves. Beta-catenin expression was also investigated in OSCC cell lines by Real-Time PCR. An additional analysis of the DNA content was performed on 22 representative OSCCs/OPSCCs by DNA-image-cytometric analysis. Results and Discussion. All carcinomas exhibited significant alterations of beta-catenin expression (P < 0.05). Beta-catenin protein was mainly detected in the cytoplasm of cancerous cells and only focal nuclear positivity was observed. Higher cytoplasmic expression correlated significantly with poor histological differentiation, advanced stage, and worst patient outcome (P < 0.05). By Real-Time PCR significant increase of beta-catenin mRNA was detected in OSCC cell lines and in 45% of surgical specimens. DNA ploidy study demonstrated high levels of aneuploidy in beta-catenin overexpressing carcinomas. Conclusions. This is the largest study reporting significant association between beta-catenin expression and clinical-pathological factors in patients with OSCCs/OPSCCs.
Related Links	http://dx.doi.org/10.1155/2014/948264
Starting Page	948264
File Format	PDF
ISSN	23146133
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2014
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2014-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene.

Excess beta-catenin promotes accumulation of transcriptionally active p53.

CD133 Expression in Normal Skin and in Epithelial Cutaneous Tumors

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.

A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations

Somatostatin Receptor-Based Molecular Imaging and Therapy for Neuroendocrine Tumors

Psychometric Properties of Questionnaires on Functional Health Status in Oropharyngeal Dysphagia: A Systematic Literature Review

beta-catenin is a target for the ubiquitin-proteasome pathway.

Beta-Catenin and Epithelial Tumors: A Study Based on 374 Oropharyngeal Cancers

Similar Documents

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene.

Excess beta-catenin promotes accumulation of transcriptionally active p53.

CD133 Expression in Normal Skin and in Epithelial Cutaneous Tumors

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.

A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations

Somatostatin Receptor-Based Molecular Imaging and Therapy for Neuroendocrine Tumors

Psychometric Properties of Questionnaires on Functional Health Status in Oropharyngeal Dysphagia: A Systematic Literature Review

beta-catenin is a target for the ubiquitin-proteasome pathway.

Beta-Catenin and Epithelial Tumors: A Study Based on 374 Oropharyngeal Cancers