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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Ketterling, J.A. Mamou, J. |
| Copyright Year | 2007 |
| Description | Author affiliation: Riverside Res. Inst., New York (Ketterling, J.A.; Mamou, J.) |
| Abstract | Current acoustic contrast agents are designed to be used in the low-MHz range (< 10 MHz) but there is a growing interest in using agents with high-frequency ultrasound (HFU, > 15 MHz). Polymer-shelled contrast agents represent the newest generation of agents and their HFU response has been relatively unexplored. Experiments were performed with polycaprolactone-shelled agents (POINT Biomedical, San Carlos, CA) having mean diameters 0.56, 1.1, and 3.4 mum. The agents were heavily diluted in water and passed through a flow system that permitted the backscatter from single agents to be digitized. The agents were exposed to 40 -MHz tone bursts of 1, 3, 5, 10, 15, and 20 cycles at peak-negative pressures of 0.6 to 6.3 MPa. At each exposure condition and with each contrast agent, 1000 valid single-bubble backscatter events were digitized and then analyzed for subharmonic content. The results showed that the likelihood of a subharmonic event increased as the number of cycles increased. All three agents had a subharmonic response for tone bursts of 10 to 20 cycles. A subharmonic was most likely at 3.9 MPa for the 3.4 mum agent and 1.7 MPa for the 0.56 and 1.1 mum agents. The results indicate that polymer-shelled agents have the potential to be used for HFU nonlinear imaging. |
| Starting Page | 1077 |
| Ending Page | 1080 |
| File Size | 150462 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424413836 |
| ISSN | 10510117 |
| DOI | 10.1109/ULTSYM.2007.272 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2007-10-28 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Polymers Ultrasonic imaging Backscatter High-resolution imaging Imaging phantoms Transducers Reservoirs Acoustic imaging Pumps Biomedical engineering |
| Content Type | Text |
| Resource Type | Article |
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