Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Wang, M.H. Hedlund, L.W. Palmeri, M.L. Guy, C.D. Liu Yang Diehl, A.M. Nightingale, K.R. |
| Copyright Year | 2007 |
| Description | Author affiliation: Duke Univ., Durham (Wang, M.H.) |
| Abstract | Liver fibrosis is currently staged using needle biopsy, a highly invasive procedure with a number of disadvantages. Measurement of liver stiffness changes which accompany progression of the disease may provide a quantitative and noninvasive method to assess the health of the liver. The purpose of this study is to investigate the correlation between radiation force derived shear wave speed and disease related changes in the liver. Liver fibrosis was induced in 10 rats using carbon tetrachloride (CC14), while 5 rats acted as controls. Liver stiffness was measured in vivo in all rats after a treatment period of 8 weeks using a modified Siemens SONOLINE Antares scanner. The animals were sacrificed after imaging and liver samples were taken for fibrosis staging using the Batts and Ludwig scale and collagen quantification using Sirius red staining. At the end of the treatment period, 4 rats had healthy livers (stage F0), while 8 had severe fibrosis (F3), and the rest had light to moderate fibrosis (Fl and F2). The mean measured liver stiffness for the F0 group was 1.2plusmn 0.1 kPa, and for F3 livers was 1.6plusmn 0.2 kPa. The difference in population means of F0 and F3 liver stiffness was significant (p < 0.01), suggesting that radiation force can be used to differentiate FO and F3 livers. However, the non- quantitative nature of fibrosis staging using the Batts and Ludwig method coupled with the relatively small changes in liver stiffness between F0 and F3 livers may make detecting stiffness differences between livers with light to moderate stage fibrosis (Fl and F2) difficult. Nevertheless, other quantitative measures of the liver health exist, which may better reflect changes observed in liver stiffness than fibrosis stage. In this study, liver stiffness was found to be strongly correlated with the amount of collagen in the liver measured by Sirius red staining (r = 0.7, p < 0.01). The relationship between radiation force measured liver stiffness and other quantitative parameters characterizing the liver health are currently being explored. |
| Starting Page | 562 |
| Ending Page | 565 |
| File Size | 1052830 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424413836 |
| ISSN | 10510117 |
| DOI | 10.1109/ULTSYM.2007.146 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2007-10-28 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Rats Liver diseases Force measurement Needles Biopsy Acoustic measurements In vivo Animals Optical coupling Current measurement |
| Content Type | Text |
| Resource Type | Article |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|